68 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria

    Alam García-Heredia et al.
    Peptidoglycan precursor synthesis occurs in both growing and non-growing regions of the mycobacterial cell surface.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Bacterial autolysins trim cell surface peptidoglycan to prevent detection by the Drosophila innate immune system

    Magda Luciana Atilano et al.
    To avoid recognition by the immune system, bacteria use autolysins to trim fragments of peptidoglycans that are exposed on the bacterial cell wall.
    1. Microbiology and Infectious Disease

    Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

    Catherine Baranowski et al.
    Polar elongating mycobacteria (Mycobacterium smegmatis) require specific cell wall chemistries, those catalyzed by targets of critical antibiotics, to maintain rod shape at aging sites of the bacillus.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis

    Cara C Boutte et al.
    Cell wall biosynthesis in mycobacteria is regulated by an unusual post-translational regulatory system that contributes to antibiotic tolerance during stress.
    1. Microbiology and Infectious Disease

    A mutant Escherichia coli that attaches peptidoglycan to lipopolysaccharide and displays cell wall on its surface

    Marcin Grabowicz et al.
    A single mutation in Escherichia coli connects two essential cell envelope assembly pathways and confers vancomycin resistance by displaying molecular decoys at the cell surface.
    1. Microbiology and Infectious Disease

    Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

    Andrew N Gray et al.
    The protein CpoB regulates PBP1B activity in response to the Tol energy state, which facilitates feedback and synchronicity between envelope constriction processes during Gram-negative bacterial cell division.
    1. Immunology and Inflammation
    2. Neuroscience

    Peptidoglycan sensing by octopaminergic neurons modulates Drosophila oviposition

    C Leopold Kurz et al.
    Female fruit flies sense bacteria-derived peptidoglycan via the octopaminergic neurons to adapt their egg laying behavior to their infection status.
    1. Microbiology and Infectious Disease

    Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli

    Jean-Emmanuel Hugonnet et al.
    Production of the L,D-transpeptidase YcbB and elevated synthesis of the (p)ppGpp alarmone reveals a new mode of peptidoglycan polymerization that bypasses the D,D-transpeptidase activity of PBPs and leads to broad-spectrum β-lactam resistance in Escherichia coli.
    1. Plant Biology

    Host-induced bacterial cell wall decomposition mediates pattern-triggered immunity in Arabidopsis

    Xiaokun Liu et al.
    Arabidopsis lysozyme LYS1 generates soluble peptidoglycan fragments to mediate pattern-triggered immunity.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Tuberculosis: Breaking down walls

    Moagi Tube Shaku, Bavesh Davandra Kana
    A better understanding of the mechanisms underpinning the growth of mycobacteria could help identify targets for new antibiotics.
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