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Attention-grabbing tasks produce rapid opioid-mediated analgesia via the descending pain modulation network to alter spinal neuronal activity.

The health benefits of caloric restriction, including decreasing body fat and blood glucose, differ between males and females and this difference depends on the age at which caloric restriction begins.

A GWAS meta-analysis for OPLL identified fourteen significant genomic loci and a subsequent Mendelian randomization study provided genetic evidence for a causal effect of obesity on the pathogenesis of OPLL, especially one of its subtypes, thoracic OPLL.

A novel synthetic DNA cassette of CTCF-binding sites combined with the drug-controllable induction system of heterochromatin enabled switchable blocking of chromatin conformation and gene-enhancer interaction.

Cooperation between model-free and model-based control systems is boosted by enhancing dopamine levels.

Time-course phosphoproteomics reveals that selective dephosphorylation is critical for directing the MI/MII transition and that, through its inherent phospho-threonine preference, PP2A-B55 imposes specific phosphoregulated behaviors that distinguish the two meiotic divisions.

Biochemical and microscopy-based approaches in mouse and human macrophages reveal that glycine cytoprotection acts at the level of the newly identified pan-death protein NINJ1 to inhibit multiple lytic cell death pathways, thereby resolving a long-standing mechanism of glycine cytoprotection.

The categorical organization of the ventral occipito-temporal cortex, typically thought to be a visual region, is actually partially independent of visual input and even visual experience.

An analysis of the first complete synaptic resolution connectome of Drosophila's navigation circuit uncovers neural network motifs supporting broadly relevant sensorimotor computations.

Analysis of chromerid algal genomes reveals how apicomplexans have evolved from free-living algae into successful eukaryotic parasites via massive losses and re-inventing functional roles of genes.