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    1. Cell Biology
    2. Developmental Biology

    FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis

    Melissa Kelley, John Yochem ... David S Fay
    A fibrillin-related protein, FBN-1, is a key component of the apical extracellular matrix and prevents epidermal cell deformation by biomechanical forces during morphogenesis of the C. elegans embryo.
    1. Neuroscience

    An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction

    Steven R Sando, Nikhil Bhatla ... H Robert Horvitz
    By driving the localized contraction of subcellular muscle regions, a single motor neuron reverses the flow of material in the Caenorhabditis elegans pharynx, a neuromuscular pump, converting feeding into spitting.
    1. Neuroscience

    Cadherin preserves cohesion across involuting tissues during C. elegans neurulation

    Kristopher M Barnes, Li Fan ... Zhirong Bao
    A coordinated tissue movement during C. elegans central nervous system internalization reveals a novel role for HMR-1/cadherin in maintaining cohesion, and extends the concept of neurulation beyond vertebrates.
    1. Genetics and Genomics

    Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization

    Mark Gormley, Tom Dudding ... Caroline Bull
    Mendelian randomization suggests the possibility that the observational effects of obesity and related metabolic traits in head and neck cancer risk are overestimated.
    1. Ecology

    The return to water in ancestral Xenopus was accompanied by a novel mechanism for producing and shaping vocal signals

    Ursula Kwong-Brown, Martha L Tobias ... Darcy B Kelley
    When ancestral Xenopus returned to water ~170mya, they evolved a new method for producing courtship calls underwater without airflow, using vibrations that also preserve essential acoustic information on species identity.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    A receptor and neuron that activate a circuit limiting sucrose consumption

    Ryan M Joseph, Jennifer S Sun ... John R Carlson
    Although sugar-sensing taste neurons typically promote feeding, a taste neuron in the Drosophila pharynx limits feeding via the IR60b receptor; thus, revealing a new element in the circuit logic of feeding control.
    1. Neuroscience

    Pharyngeal mechanosensory neurons control food swallow in Drosophila melanogaster

    Jierui Qin, Tingting Yang ... Wei Zhang
    Multi-dendritic cibarium neurons in the fly pharynx sense mechanical force during swallowing by NOMPC, piezo, and Tmc, besides, these neurons interact with motor neurons to control food swallow.
    1. Physics of Living Systems

    Overtone focusing in biphonic tuvan throat singing

    Christopher Bergevin, Chandan Narayan ... Brad Story
    In light of the mysteries underlying the biphonic nature of Tuvan throat song, information from multiple modalities is combined to explain how this remarkable phenomenon is achieved biomechanically.
    1. Developmental Biology
    2. Evolutionary Biology

    Bichir external gills arise via heterochronic shift that accelerates hyoid arch development

    Jan Stundl, Anna Pospisilova ... Robert Cerny
    Unique heterochrony in the cranial segments in bichirs triggers the early formation of their external gills, and might be informative about developmental mechanisms facilitating increased breathing capacity.