2,372 results found
    1. Genetics and Genomics

    Single cell functional genomics reveals the importance of mitochondria in cell-to-cell phenotypic variation

    Riddhiman Dhar, Alsu M Missarova ... Lucas B Carey
    A genome-wide quantitative microscopy screen implicates mitochondria in single cell variation in proliferation and drug resistance in yeast.
    1. Developmental Biology

    Embryonic geometry underlies phenotypic variation in decanalized conditions

    Anqi Huang, Jean-François Rupprecht, Timothy E Saunders
    Gene regulatory networks incorporate information of the embryonic geometrical parameters to give rise to differential individual patterning outputs under decanalized genetics backgrounds.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits

    Rashmi Sukumaran, Achuthsankar S Nair, Moinak Banerjee
    Genomic differences in stroke and its comorbid conditions can aid in refining the socio-economic interpretation of risk among different ethnicities and can assist in distinguishing their phenotypic variation.
    1. Developmental Biology
    2. Physics of Living Systems

    Global constraints within the developmental program of the Drosophila wing

    Vasyl Alba, James E Carthew ... Madhav Mani
    A novel mathematical strategy for the integrated analysis of adult body structures quantifies the degree and nature of developmental robustness and its evolutionary implications.
    1. Genetics and Genomics
    2. Neuroscience

    The structure of behavioral variation within a genotype

    Zachary Werkhoven, Alyssa Bravin ... Benjamin L de Bivort
    Multidimensional analysis of data from high-throughput behavioral assays reveals many independent axes of behavioral variation among inbred animals reared in the same environment.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Environment determines evolutionary trajectory in a constrained phenotypic space

    David T Fraebel, Harry Mickalide ... Seppe Kuehn
    Experimental evolution shows that when selection acts on two traits constrained by a trade-off, the direction of phenotypic evolution depends on the environment.
    1. Evolutionary Biology

    Recent shifts in the genomic ancestry of Mexican Americans may alter the genetic architecture of biomedical traits

    Melissa L Spear, Alex Diaz-Papkovich ... Ryan D Hernandez
    Admixture dynamics have recently changed over time in Mexican Americans resulting in an impact on the genetic architecture of phenotypic variation.
    1. Genetics and Genomics
    2. Plant Biology

    Cytoplasmic genetic variation and extensive cytonuclear interactions influence natural variation in the metabolome

    Bindu Joseph, Jason A Corwin ... Daniel J Kliebenstein
    Genes located within cellular organelles impact phenotype more than expected due to their interactions with nuclear genes.
    1. Genetics and Genomics

    Regulatory network structure determines patterns of intermolecular epistasis

    Mato Lagator, Srdjan Sarikas ... Călin C Guet
    Greater phenotypic variation is exposed by mutations in a gene regulatory system compared to mutations in its constitutive components, namely the transcription factor and the promoter, alone.
    1. Genetics and Genomics

    Genomic regions controlling shape variation in the first upper molar of the house mouse

    Luisa F Pallares, Ronan Ledevin ... Sabrina Renaud
    An association mapping in wild mice revealed the first candidate loci for within-population molar shape variation and the phenotypic impact of such candidate loci was quantified and validated.

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