117 results found
    1. Physics of Living Systems
    2. Neuroscience

    Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

    Amanda H Lewis, Jörg Grandl
    Tension is the activating stimulus of Piezo1 mechanosensitive ion channels and resting membrane tension modulates overall channel sensitivity to mechanical stimulation.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Chemical activation of the mechanotransduction channel Piezo1

    Ruhma Syeda et al.
    A chemical activator of the mechanosensitive Piezo1 ion channel has been identified.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Piezo Ion Channels: Portraits of a pressure sensor

    Alexander T Chesler, Marcin Szczot
    Near atomic-resolution structures have provided insights into the mechanisms by which the Piezo1 ion channel senses and responds to mechanical stimuli.
    Insight
    Available as:
    • HTML
    • PDF
    1. Structural Biology and Molecular Biophysics

    Structure-based membrane dome mechanism for Piezo mechanosensitivity

    Yusong R Guo, Roderick MacKinnon
    Mechanosensitive Piezo channel induces local membrane curvature to mediate mechanical gating.
    1. Neuroscience

    Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio)

    Lin Cong et al.
    The integration of a novel high spatiotemporal resolution volume imaging technique and a fast 3D tracking system allows capturing whole brain neural activities in a freely behaving larval zebrafish.
    1. Neuroscience

    Live calcium and mitochondrial imaging in the enteric nervous system of Parkinson patients and controls

    An-Sofie Desmet et al.
    In contrast to previous post-mortem or fixed tissue histochemical reports, live calcium and mitochondrial imaging data suggest that the enteric nervous system is not generally affected in Parkinson's disease patients.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Control of AMPA receptor activity by the extracellular loops of auxiliary proteins

    Irene Riva et al.
    Glutamate receptor auxiliary proteins exert their effects on receptor gating through two divergent extracellular loops, explaining subunit specificity and allowing the construction of null versions that form complexes normally but do not modify receptor gating.
    1. Neuroscience

    A predictive focus of gain modulation encodes target trajectories in insect vision

    Steven D Wiederman et al.
    Visual neurons in the dragonfly predict the path of a moving target, even when it is occluded or crosses from one eye to the other.
    1. Cell Biology

    The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

    Wenbao Hu et al.
    XIAP/TRIP-Br1-mediated degradation of multiple adenylyl cyclase isoforms is a previously unrecognised general mechanism for controlling adenylyl cyclase expression and the homeostasis of cAMP signalling.

Refine your results by:

Type
Research categories