114 results found
    1. Physics of Living Systems

    Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy

    Antonia Franziska Eckert, Peng Gao ... Gerd Ulrich Nienhaus
    A robust fluorescence microscopy-based data acquisition and analysis framework affords the precise measurement of cell surface receptor affinities toward their cognate ligands and their densities in live cells/tissues.
    1. Cell Biology

    Stratification of enterochromaffin cells by single-cell expression analysis

    Yan Song, Linda J. Fothergill ... Gene W. Yeo
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    A functional genomics screen in planarians reveals regulators of whole-brain regeneration

    Rachel H Roberts-Galbraith, John L Brubacher, Phillip A Newmark
    A gene expression-guided functional screen identifies factors and cell types that regulate diverse aspects of neural regeneration in planarians.
    1. Stem Cells and Regenerative Medicine

    A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

    Henrik Renner, Martha Grabos ... Jan M Bruder
    Automated liquid handling, whole mount staining, and clearing allow unbiased 3D quantitation of cell markers in human neural organoids with diameters of up to 1 mm at the single-cell level.
    1. Neuroscience

    The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons

    Emily G Berghoff, Lori Glenwinkel ... Oliver Hobert
    Circuit transcription factors may define the differentiation and assembly of distinct neurons into functional circuitry.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    A complete toolset for the study of Ustilago bromivora and Brachypodium sp. as a fungal-temperate grass pathosystem

    Franziska Rabe, Jason Bosch ... Armin Djamei
    The establishment of Ustilago bromivora and Brachypodium as a biotrophic model system provides the foundation for studying new aspects of plant-pathogen interactions and for answering questions about fungal sex and speciation.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

    Pierre Khoueiry, Charles Girardot ... Eileen EM Furlong
    Interspecies comparison of transcription factor occupancy during embryogenesis reveals potential co-operative relationships between factors and uncovers the inherent plasticity of developmental enhancers to overcome divergence in transcription factor occupancy.
    1. Neuroscience

    In silico analysis of the transcriptional regulatory logic of neuronal identity specification throughout the C. elegans nervous system

    Lori Glenwinkel, Seth R Taylor ... Oliver Hobert
    Neuron type-specific gene batteries share cis-regulatory motifs.
    1. Ecology
    2. Genetics and Genomics

    Individual differences in honey bee behavior enabled by plasticity in brain gene regulatory networks

    Beryl M Jones, Vikyath D Rao ... Gene E Robinson
    Integration of automatic behavioral tracking with brain molecular profiling reveals the role of gene regulatory network plasticity in the regulation of behavioral phenotypes.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling

    Dongsheng Guo, Katelyn Daman ... Charles P Emerson Jr
    iMyoblasts, a novel iPS-derived PAX3 muscle stem cell for gene editing, muscle engraftment, and stem cell therapeutics to treat muscle injury and muscular dystrophies.

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