A robust fluorescence microscopy-based data acquisition and analysis framework affords the precise measurement of cell surface receptor affinities toward their cognate ligands and their densities in live cells/tissues.
Automated liquid handling, whole mount staining, and clearing allow unbiased 3D quantitation of cell markers in human neural organoids with diameters of up to 1 mm at the single-cell level.
The establishment of Ustilago bromivora and Brachypodium as a biotrophic model system provides the foundation for studying new aspects of plant-pathogen interactions and for answering questions about fungal sex and speciation.
Pierre Khoueiry, Charles Girardot ... Eileen EM Furlong
Interspecies comparison of transcription factor occupancy during embryogenesis reveals potential co-operative relationships between factors and uncovers the inherent plasticity of developmental enhancers to overcome divergence in transcription factor occupancy.
Integration of automatic behavioral tracking with brain molecular profiling reveals the role of gene regulatory network plasticity in the regulation of behavioral phenotypes.
Dongsheng Guo, Katelyn Daman ... Charles P Emerson Jr
iMyoblasts, a novel iPS-derived PAX3 muscle stem cell for gene editing, muscle engraftment, and stem cell therapeutics to treat muscle injury and muscular dystrophies.