Pituitary organoids help identify NFKB2 as a new actor during pituitary development, and mutations of this gene as the cause for pituitary deficit observed in patients with DAVID syndrome.
A gene regulatory network model provides a simplified explanation of the molecular interactions that orchestrate muscle development in the sea urchin embryo.
Ruth M Williams, Martyna Lukoseviciute ... Marianne E Bronner
A single-cell transcriptomic resource of the early chick epiblast from mid-gastrulation through neurulation highlighting emergence of the neural plate border territory, with emphasis on neural crest specification.
Md Rakibul Hasan, Maarit Takatalo ... David PC Rice
RAB23 regulates calvarial bone and suture development both independently through, and by cross-talk between, Hedgehog and fibroblast growth factor signaling.
Fernanda M Bosada, Karel van Duijvenboden ... Vincent M Christoffels
Modest changes in expression of interacting dose-dependent transcription factors Tbx5 and Prrx1, caused by disease-associated common regulatory variants, significantly impact on the cardiac gene regulatory network and disease susceptibility.
The terminal selector-type transcription factor UNC-3/Ebf partially modifies the suite of its target genes at different life stages to establish and maintain the identity of C. elegans motor neurons.
Davide M Coda, Tessa Gaarenstroom ... Caroline S Hill
NODAL/Activin-induced SMAD2 binding directly drives remodeling of both open and closed chromatin and does not directly correlate with temporal patterns of gene expression upon prolonged signaling.
A molecular mechanism that involves highly conserved transcription factors enables cholinergic motor neurons of the nematode Caenorhabditis elegans to become and remain functional.
