9 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research

    Franziska Mohring et al.
    Optimised genome editing in P. knowlesi enables transgenic expression of a lead P. vivax vaccine candidate, revealing roles in host cell tropisms and providing tools for scalable vaccine efficacy testing.
    1. Epidemiology and Global Health

    Local human movement patterns and land use impact exposure to zoonotic malaria in Malaysian Borneo

    Kimberly M Fornace et al.
    Local human movement into mosquito habitats around forest edges intensifies interactions between pathogens, insects and people, increasing exposure risks to the zoonotic malaria Plasmodium knowlesi in Malaysian Borneo.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Motility precedes egress of malaria parasites from oocysts

    Dennis Klug, Friedrich Frischknecht
    A surface protein triggers intra-oocyst motility of Plasmodium sporozoites to ensure parasite egress from oocysts.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody

    Paola Favuzza et al.
    The structure of the promising malaria blood-stage vaccine candidate antigen PfCyRPA and the characterization of a protective epitope are facilitating research on its essential role in parasite invasion, and will guide future epitope-focused vaccine design.
    1. Microbiology and Infectious Disease

    A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi

    Annemarie Voorberg-van der Wel et al.
    This comprehensive transcriptomic resource of dormant and replicating malaria liver parasites highlights the dearth of pathways that operate in the hypnozoites and the need to investigate druggability (i.e. selectivity and safety) of core pathways in malaria parasites.
    1. Ecology
    2. Epidemiology and Global Health

    Tracking zoonotic pathogens using blood-sucking flies as 'flying syringes'

    Paul-Yannick Bitome-Essono et al.
    A field study coupled with a molecular analysis demonstrates that using hematophagous flies as 'flying syringes' could be used to investigate blood-borne pathogen diversity in wild vertebrates and act as an early detection tool of zoonotic pathogens.
    1. Cell Biology
    2. Plant Biology

    Multi-functional roles for the polypeptide transport associated domains of Toc75 in chloroplast protein import

    Yamuna D Paila et al.
    The conserved polypeptide transport associated (POTRA) domains of the protein import channel, Toc75, are essential for protein import into chloroplasts.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Genomic epidemiology of artemisinin resistant malaria

    MalariaGEN Plasmodium falciparum Community Project
    Plasmodium falciparum kelch13 mutations that cause artemisinin resistant malaria in Southeast Asia show markedly different patterns of evolutionary selection in Africa.
    1. Microbiology and Infectious Disease

    The Plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development

    Devendra Kumar Gupta et al.
    LISP2 expression marks the beginning of awakening of dormant hypnozoite to developing malaria liver stages, which are susceptible to a novel prophylactic drug, Plasmodium PI4K inhibitor.

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