21 results found
    1. Genetics and Genomics

    Nuclear genomic signals of the ‘microturbellarian’ roots of platyhelminth evolutionary innovation

    Christopher E Laumer et al.
    A phylogeny of all major groups of flatworms based on hundreds of genes sheds new light the early evolution of this important metazoan phylum, with particular significance for the original of vertebrate parasitism.
    1. Genetics and Genomics

    Phylogeny: Unravelling a can of worms

    Alejandro Sánchez Alvarado
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    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni

    George R Wendt et al.
    The specification of tegumental progenitor cells in Schistosoma mansoni relies on a pair of flatworm-specific transcription factors that are related to genes regulating epidermal specification in free-living flatworms.
    1. Developmental Biology
    2. Evolutionary Biology

    Extraocular, rod-like photoreceptors in a flatworm express xenopsin photopigment

    Kate A Rawlinson et al.
    A new opsin receptor is light-sensitive and expressed in a unique type of photoreceptor in a flatworm that encloses over 400 sensory cilia within its cell membrane.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Ancient origins of arthropod moulting pathway components

    André Luiz de Oliveira et al.
    Evolutionary reconstruction of the ecdysis pathway shows that its major elements are present in the majority of metazoans, providing evidence that they originated much earlier than currently assumed.
    1. Microbiology and Infectious Disease

    Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

    Wannaporn Ittiprasert et al.
    Gene knock-out of the omega-1 ribonuclease of Schistosoma mansoni eggs resulted in immunologically impaired phenotype, showcasing the novel application of CRISPR/Cas9 genome editing and utility for functional genomics in schistosomes.
    1. Ecology

    Rarity is a more reliable indicator of land-use impacts on soil invertebrate communities than other diversity metrics

    Andrew Dopheide et al.
    Rarity metrics reveal pervasive negative impacts of agricultural land use on soil invertebrate communities, whereas widely-used richness and diversity metrics underestimate the magnitude of these impacts.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Cell-type diversity and regionalized gene expression in the planarian intestine

    David J Forsthoefel et al.
    Application of laser-capture microdissection to planarian intestinal tissue provides a new tool for analysis of tissue-specific gene expression in flatworms, and a new resource to advance investigations of gastrointestinal regeneration.
    1. Microbiology and Infectious Disease

    Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity

    Patpicha Arunsan et al.
    Gene knockout of liver fluke granulin by CRISPR/Cas9 attenuates the virulence of infection with a carcinogenic liver fluke.

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