218 results found
    1. Cell Biology

    Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion

    Yang Zhang, Pengfei Liang ... Huanghe Yang
    A previously unknown calcium channel in human placental trophoblasts provides a calcium source for activating TMEM16F lipid scramblase that flip-flops phospholipids on cell surface, demonstrating a physiological mechanism that helps to understand how lipid dynamics regulates cell fusion.
    1. Genetics and Genomics

    Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes

    Nathan M Shugarts Devanapally, Aishwarya Sathya ... Antony M Jose
    Transport of double-stranded RNA from parental circulation to progeny using the transmembrane protein SID-1 can occur through multiple routes during C. elegans development and buffer heritable changes in gene expression.
    1. Developmental Biology
    2. Genetics and Genomics

    Feedback between a retinoid-related nuclear receptor and the let-7 microRNAs controls the pace and number of molting cycles in C. elegans

    Ruhi Patel, Himani Galagali ... Alison R Frand
    A genetic oscillator composed of NHR-23 and let-7 family of microRNAs links the molting cycle timer and the heterochronic pathway to regulate the pace of molting in C. elegans and ensure that worms molt only four times.
    1. Neuroscience

    Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body

    Michael-John Dolan, Shahar Frechter ... Gregory SXE Jefferis
    The generation and systematic characterisation of driver lines labelling a large number of neurons in the Drosophila innate olfactory processing centre bridges electron microscopy neuronal reconstructions, circuits and behaviour.
    1. Cell Biology
    2. Neuroscience

    Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival

    Moloy T Goswami, Eric Weh ... Thomas J Wubben
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression

    Srs2 binding to PCNA and its sumoylation contribute to RPA antagonism during the DNA damage response

    Jiayi Fan, Nalini Dhingra ... Xiaolan Zhao
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Evolutionary Biology
    2. Genetics and Genomics

    Two novel, tightly linked, and rapidly evolving genes underlie Aedes aegypti mosquito reproductive resilience during drought

    Krithika Venkataraman, Nadav Shai ... Leslie B Vosshall
    Two novel, tightly linked, and rapidly evolving genes encoding small secreted proteins are necessary for female mosquitoes to protect their retained eggs during extended periods of drought.
    1. Computational and Systems Biology
    2. Developmental Biology

    Diversity in Notch ligand-receptor signaling interactions

    Rachael Kuintzle, Leah A Santat, Michael B Elowitz
    The Notch signaling pathway can use its various ligands, receptors, and Fringe proteins to generate diverse intra- and intercellular signaling behaviors.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Hematopoietic plasticity mapped in Drosophila and other insects

    Dan Hultmark, István Andó
    A critical analysis of recent single-cell transcriptomic studies of Drosophila blood cells confirms the extreme plasticity of the major phagocyte class, identifies a new class of blood cell, and suggests relationships to blood cells in other insects.
    1. Neuroscience
    2. Evolutionary Biology

    A single-cell transcriptomic atlas reveals resident dendritic-like cells in the zebrafish brain parenchyma

    Mireia Rovira, Giuliano Ferrero ... Valérie Wittamer
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling

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