Multiple axonal guidance receptors control the local and selective translation of mRNAs by binding to ribosomes, specific mRNAs and RNA-binding proteins.
The ES6S region of the small subunit ribosome makes a place for the threading and secondary structure unwinding of mRNA, which regulates genome-wide translation.
Interplay between histone demethylation and chromatin remodeling shapes the chromatin environment of the essential stress regulator ETHYLENE-INSENSITIVE2.
Biochemical fractionation of vesicle sub-populations and in vitro reconstitution studies reveal that Lupus La protein mediates the selective sorting of miR-122 into extracellular vesicles in vitro and in vivo.
Human ferritin light chain (FTL) mRNA translation is regulated via its 5'-untranslated region (5'-UTR) by three mechanisms: RNA folding, iron response protein binding, and eukaryotic translation initiation factor eIF3 binding.
Telomeric TRF1 controls the transcriptional programmes of pluripotent stem cells by recruiting PRC2 to pluripotency and differentiation genes by controlling the expression of those gene sites and the binding of TERRA RNAs to them.
RNAs enriched at cell protrusions are translated regardless of their location in the cytoplasm but are dynamically repressed in retracting protrusions and incorporated into heterogeneous RNA clusters.
The expansion of the anterior Drosophila CNS is driven by increased progenitor generation and prolonged proliferation, mediated by brain-restricted genes and the PRC2.
Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.
