208 results found
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

    Judith Schütte, Huange Wang ... Berthold Göttgens
    A computer model built on insights gained from comprehensive experimental analysis reveals mechanisms of blood stem cell regulation.
    1. Developmental Biology
    2. Genetics and Genomics

    Transcriptional control of compartmental boundary positioning during Drosophila wing development

    Gustavo Aguilar, Michèle Sickmann ... Martin Müller
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state

    Ruben Sebastian-Perez, Shoma Nakagawa ... Maria Pia Cosma
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    • Incomplete
    1. Cell Biology

    Novel Nuclear Roles for Testis-Specific ACTL7A and ACTL7B Supported by In Vivo Characterizations and AI Facilitated In Silico Mechanistic Modeling with Implications for Epigenetic Regulation in Spermiogenesis

    Pierre Ferrer, Srijana Upadhyay ... Tracy M. Clement
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Chromosomes and Gene Expression

    High-precision mapping of nuclear pore-chromatin interactions reveals new principles of genome organization at the nuclear envelope

    Swati Tyagi, Juliana S. Capitanio ... Martin W. Hetzer
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Chromosomes and Gene Expression

    GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo

    Marissa M Gaskill, Tyler J Gibson ... Melissa M Harrison
    Following fertilization, the pioneering transcription factors GAGA factor (GAF) and Zelda are independently required to reprogram the zygotic genome of Drosophila and activate the first wave of gene expression.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Novel discoveries and enhanced genomic prediction from modelling genetic risk of cancer age-at-onset

    Ekaterina S. Maksimova, Sven E. Ojavee ... Matthew R. Robinson
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Quantitative control of noise in mammalian gene expression by dynamic histone regulation

    Deng Tan, Rui Chen ... Wei Huang
    Ubiquitous transcriptional factor-CBP/p300 interaction induces epigenetic and transcriptional bimodality, which can be utilized to tune mean gene expression and noise independently.
    1. Cell Biology
    2. Developmental Biology

    Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis

    Jeongkyung Lee, Ruya Liu ... Vijay K. Yechoor
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome

    Laura A Lavery, Kerstin Ure ... Huda Y Zoghbi
    Dnmt3a regulates gene expression in inhibitory neurons by writing all mCH and some mCG, and MeCP2 reads some of these mCH sites driving a portion of these gene expression changes.
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