786 results found
    1. Ecology
    2. Evolutionary Biology

    Fin whale song evolution in the North Atlantic

    Miriam Romagosa, Sharon Nieukirk ... Mónica A Silva
    The rapid and gradual fin whale songs changes adopted by individuals of a certain area provide evidence of vocal learning in this species, elucidate patterns of song evolution and hints on the limits of song variation.
    1. Neuroscience

    Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation

    Elizabeth C Marin, Billy J Morris ... Gregory SXE Jefferis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Genetics and Genomics
    2. Evolutionary Biology

    Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population

    Gabriel Birzu, Harihara Subrahmaniam Muralidharan ... Devaki Bhaya
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology

    TopOMetry systematically learns and evaluates the latent dimensions of single-cell atlases

    Davi Sidarta-Oliveira, Ana Domingos, Licio A Velloso
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice

    Ana S Machado, Dana M Darmohray ... Megan R Carey
    Analysis of 3D paw kinematics and whole-body coordination in freely walking mice isolates specific features of gait ataxia and supports the hypothesis that the cerebellum provides an internal forward model for motor control.
    1. Medicine

    Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical

    Elisabeth Gludovacz, Kornelia Schuetzenberger ... Thomas Boehm
    Because heparin-binding motif mutations of human diamine oxidase (hDAO) block cellular uptake and strongly decrease clearance in vivo, modified recombinant hDAO might be a good candidate for the treatment of symptoms induced by excessive endogenous histamine release.
    1. Genetics and Genomics

    A population modification gene drive targeting both Saglin and Lipophorin impairs Plasmodium transmission in Anopheles mosquitoes

    Emily I Green, Etienne Jaouen ... Eric Marois
    Strong reduction in malaria transmission by genetically modified mosquitoes is achieved in the laboratory using a dual gene drive that simultaneously propagates an antiparasitic factor and a parasite-detrimental mosquito mutation.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    A nucleation barrier spring-loads the CBM signalosome for binary activation

    Alejandro Rodriguez Gama, Tayla Miller ... Randal Halfmann
    Switches in cell state downstream of pathogen exposure are driven by a deeply conserved disorder-to-order phase transition in an immunity signaling network.
    1. Ecology
    2. Microbiology and Infectious Disease

    Adaptability of non-genetic diversity in bacterial chemotaxis

    Nicholas W Frankel, William Pontius ... Thierry Emonet
    An experimentally constrained model shows that Escherichia coli faces fitness trade-offs in chemotaxis behaviors, and that adaptation of phenotypic diversity through altered gene regulation permits populations to resolve these trade-offs.

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