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The α1 isoform of synGAP restricts the binding of AMPA-receptors and other regulatory proteins to PSD-95, and thus regulates synaptic strength.

Resting-state capillary blood flow and oxygenation are more homogeneous in the deeper cortical layers, underpinning an important mechanism by which the microvascular network adapts to an increased local oxidative metabolism.

Inhibition of 5-HT neurons in the dorsal raphe nuclei or 5-HT terminals in the anterior cingulate cortex decreased consolation-like behaviors and reduced sociability.

EZH2 is regulated by a K20-methylation dependent proteolysis and this proteolysis process is negatively controlled by AKT-mediated S21 phosphorylation to establish a methylation-phosphorylation switch to control the PRC2 activity and hematopoiesis.

Depletion of VAPA in cancer cells induces defects in actin organization, adhesion dynamics and cell migration, together with a perturbation of phosphoinositide levels at the plasma membrane and a lack of anchoring of ER-PM contact sites to focal adhesions.

Binding of ligands to PSD-95 PDZ domains induces a conformational change within the C-terminal domain module that enables differential binding to synaptic interactors.

A one-photon three-dimensional light sculpture technique has been developed and demonstrated for high spatio-temporal resolution photostimulation and imaging of dozens of neurons in the intact mouse brain in vivo.

A nonlinear deep generative model can represent fetal–neonatal resting-state functional magnetic resonance imaging better than conventional linear models.

Anatomical projections from sensory, motor, and association cortex to the cerebellum are precisely mapped, including cortical-precerebellar connections and terminal organization, providing insight into how the cerebellum may utilize cortical information.

Integration of complementary computational approaches reveals an evolutionarily conserved interaction interface between molecular chaperones Hsp70 and Hsp40, rationalizing previous observations.