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    1. Developmental Biology
    2. Evolutionary Biology

    Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues

    Aaron L Fidler et al.
    Collagen IV is a primordial extracellular matrix component associated with the transition to animal multicellularity, and enabled the formation and evolution of epithelial tissues.
    1. Biochemistry and Chemical Biology

    YcgC represents a new protein deacetylase family in prokaryotes

    Shun Tu et al.
    A protein microarray based strategy has identified a bacterial enzyme that represents a new protein deacetylase family.
    1. Biochemistry and Chemical Biology

    Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii

    Irini Pateraki et al.
    The entire biosynthetic pathway for the diterpenoid forskolin in Coleus forskohlii has been reconstituted in yeast.
    1. Cell Biology
    2. Neuroscience

    The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning

    Jie Gao et al.
    Control of lipoprotein receptor protein levels at synapses by the E3 ubiquitin ligase IDOL is shown to be important for the plasticity of neuronal dendrites in vitro and learning and memory in mice.
    1. Neuroscience

    A platform for brain-wide imaging and reconstruction of individual neurons

    Michael N Economo et al.
    High-resolution fluorescence imaging of the complete mouse brain enables many neurons to be efficiently visualized in their entirety, revealing all targets of neurons that project widely across the brain.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

    Ryan M McCormack et al.
    Perforin-2 deficiency is lethal upon infection with pathogenic bacteria despite the presence of other bactericidal effectors.
    1. Genetics and Genomics

    Codon optimization underpins generalist parasitism in fungi

    Thomas Badet et al.
    Codon optimization through biased synonymous substitutions is a characteristic feature of the genomes of generalist fungal parasites and is associated with the colonization of multiple hosts.
    1. Human Biology and Medicine
    2. Neuroscience

    Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders

    Cian O'Donnell et al.
    Computational modeling and analysis of mouse neural population data finds that the excitation/inhibition imbalance theory of brain disorders is too limited to account for key changes in neural activity statistics.
    1. Neuroscience

    Long-range population dynamics of anatomically defined neocortical networks

    Jerry L Chen et al.
    A new microscopy system allows the activity of interconnected neurons in different brain regions to be measured simultaneously.