101 results found
    1. Biochemistry and Chemical Biology

    Exploiting functional regions in the viral RNA genome as druggable entities

    Dehua Luo, Yingge Zheng ... Dengguo Wei
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Control of the polyamine biosynthesis pathway by G2-quadruplexes

    Helen Louise Lightfoot, Timo Hagen ... Jonathan Hall
    An ensemble of conserved G2-quadruplex structures in the untranslated regions of messenger RNAs from genes in the polyamine bioysynthesis pathway sense polyamine levels and regulate polyamine synthesis in cells.
    1. Computational and Systems Biology
    2. Neuroscience

    Blood transcriptome based biomarkers for human circadian phase

    Emma E Laing, Carla S Möller-Levet ... Derk-Jan Dijk
    An unbiased modelling approach shows that only a few blood transcriptome samples are required to accurately assess the human circadian melatonin phase, even during altered sleep schedules.
    1. Cell Biology
    2. Neuroscience

    Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior

    Stephan Raiders, Erik Calvin Black ... Aakanksha Singhvi
    A peripheral sense-organ glia actively engulfs fragments of a sensory neuron ending to modify neuron shape and associated animal sensory behavior in Caenorhabditis elegans..
    1. Immunology and Inflammation

    The bacterial quorum sensing signal 2’-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection

    Arijit Chakraborty, Arunava Bandyopadhaya ... Laurence G Rahme
    The Pseudomonas aeruginosa secreted signaling molecule 2'-aminoacetophenone modulates cellular immunometabolism to promote persistence in infected tissues.
    1. Medicine
    2. Neuroscience

    Prognostication of chronic disorders of consciousness using brain functional networks and clinical characteristics

    Ming Song, Yi Yang ... Tianzi Jiang
    Behavioral, pharmacological, optogenetic, electrophysiological and computational analyses suggest that the anterior dorsal striatum is a causal node in the network responsible for evidence accumulation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The evolutionary history and genomics of European blackcap migration

    Kira Delmore, Juan Carlos Illera ... Miriam Liedvogel
    Variation in migration can evolve rapidly and traits that comprise this behaviour may be determined by standing variation at a few regulatory regions that are not common across taxonomic groups.
    1. Epidemiology and Global Health

    Identifying Plasmodium falciparum transmission patterns through parasite prevalence and entomological inoculation rate

    Benjamin Amoah, Robert S McCann ... Emanuele Giorgi
    Estimating fine-scale spatiotemporal patterns of Plasmodium falciparum transmission showed an association between entomological inoculation rate and parasite prevalence that emphasizes the value of both measures in malaria surveillance.
    1. Plant Biology

    The plant pathogen Pseudomonas aeruginosa triggers a DELLA-dependent seed germination arrest in Arabidopsis

    Hicham Chahtane, Thanise Nogueira Füller ... Luis Lopez-Molina
    Arabidopsis seed germination can be repressed by a Pseudomonas factor.

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