59 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

    Nicolas Altemose et al.
    In humans, specific sequence features can predict whether meiotic recombination occurs at sites bound by the protein PRDM9, whose DNA-binding zinc-finger domain can unexpectedly bind to gene promoters and to other copies of PRDM9.
    1. Genetics and Genomics

    Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates

    Zachary Baker et al.
    PRDM9 is widely conserved across vertebrates yet has been lost numerous times, as has its role in directing meiotic recombination.
    1. Genetics and Genomics

    ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair

    Daniel Wells et al.
    ZCWPW1 has co-evolved with PRDM9, in particular the PRDM9-SET domain, and although not involved in PRDM9's role in positioning recombination events, it is required for PRDM9's role in pairing chromosomes.
    1. Cell Biology
    2. Genetics and Genomics

    The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair

    Tao Huang et al.
    ZCWPW1 is a histone modification reader that localizes to DMC1-labelled double-strand break hotspots in a largely PRDM9-dependent manner, where it facilitates completion of synapsis by mediating DSB repair process.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment

    Yukiko Imai et al.
    Biochemical and genetic approaches uncover a chromatin remodeler for PRDM9 binding and the parallel local epigenetic modification of cytosines in mouse spermatocytes.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice

    Sona Gregorova et al.
    Prdm9-generated meiotic asynapsis of homologous chromosomes in mouse subspecific hybrids causes hybrid sterility and can be reversed by introducing random stretches of consubspecific sequence (≥ 27Mb) on four chromosomes most sensitive to asynapsis.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Cisplatin-induced DNA double-strand breaks promote meiotic chromosome synapsis in PRDM9-controlled mouse hybrid sterility

    Liu Wang et al.
    The exogenous DNA DSBs improve meiotic chromosome pairing in mouse inter-subspecific hybrids, thus providing an evidence for a DSB-dependent mechanism of the PRDM9-controlled synapsis failure and infertility.
    1. Developmental Biology
    2. Genetics and Genomics

    Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice

    Mohamed Mahgoub et al.
    The meiotic recombination landscape in vertebrates was re-engineered via the co-evolution of a dual histone H3K4/H3K36 methylation 'writer' PRDM9 and its 'reader' ZCWPW1 that facilitates efficient double strand break repair.
    1. Immunology and Inflammation

    IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

    Esther Zumaquero et al.
    IFNγ increases the responsiveness of human B cells to IL-2, TLR7/8 and IL-21 signals and therefore enhances antibody production in inflammatory settings associated with autoimmune or chronic disease.
    1. Genetics and Genomics

    Recombination, meiotic expression and human codon usage

    Fanny Pouyet et al.
    Variation in codon usage among functional categories of human genes is not due to selection for translation efficiency, but to differences in intragenic recombination rate, linked to variation in meiotic transcription level.

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