Naïve CD8⁺ T cells are dysregulated during chronic hepatitis C (HCV) infection, and this is reversible after viral clearance.

Mathematical modeling shows that local populations of the malaria parasite self-organize into a limited number of transient but distinct strains through competition for hosts in immunity space.

Longitudinal tracking of individual T-cell clones reveals the expansion of pre-existing T-cell memory in response to SARS-CoV-2 infection.

Deep learning improves estimation of T cell receptor cohort frequencies and learns the rules of VDJ recombination, potentially making it helpful for vaccine design.

A new software developed for high-throughput antibody, T cell receptor, and MHC repertoire analysis uncovers neutrality of the binding interface and intramolecular crosstalk as distinguishing properties of polyreactive antibodies.

The number of different peptides presented by major histocompatibility complex class I molecules to the immune system's T lymphocytes is inversely correlated with cell surface expression and is strongly associated with the response to infectious disease.

Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.

A new perception of the organization of T-cell receptor repertoires in mice and humans, based on high-throughput sequencing and CDR3 sequence similarity, indicates hubs of cross-species public sequences forming evolutionary conserved 'foci of attention' of T cell immunity.

Without using control cohorts, a statistical method identifies candidates for immune receptors associated with diseases from repertoire sequencing datasets.

Redundancy in the costimulatory signals that drive CD8⁺ T cell expansion is dictated by pathogen-specific cues.