18 results found
    1. Neuroscience

    PreBötzinger complex neurons drive respiratory modulation of blood pressure and heart rate

    Clément Menuet et al.
    The PreBötzinger complex, which contains neurons that are the kernel for inspiratory rhythm generation, also contains sympathoexcitatory and parasympathoinhibitory neurons that drive respiratory-phase oscillations in blood pressure and heart rate.
    1. Neuroscience

    Rhythmogenic Networks: The ins and outs of breathing

    Jan-Marino Ramirez et al.
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    1. Neuroscience

    Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice

    Srinivasan Tupal et al.
    The rhythmic patterns of activity that underlie breathing are generated and coordinated by distinct populations of neurons within the brainstem.
    1. Neuroscience

    Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratory network

    Marc Chevalier et al.
    Pacemaker neurons are present in the preBötC circuitry of mouse embryos and their role in driving respiratory network activity changes during the critical period immediately before birth.
    1. Human Biology and Medicine
    2. Neuroscience

    Opioids depress breathing through two small brainstem sites

    Iris Bachmutsky et al.
    Opioids stop breathing during overdose by silencing two small brain sites, with just 140 neurons in the breathing rhythm generator exerting the key effect.
    1. Neuroscience

    Interactions between respiratory oscillators in adult rats

    Robert TR Huckstepp et al.
    Active expiration in anesthetized rats is driven by the lateral parafacial region, but requires an additional form of excitation from another source.
    1. Neuroscience

    Insights into the dynamic control of breathing revealed through cell-type-specific responses to substance P

    Nathan A Baertsch, Jan-Marino Ramirez
    The neuromodulator substance P enhances mechanisms of recurrent excitation between breaths to control breathing frequency and stability.
    1. Neuroscience

    Laser ablation of Dbx1 neurons in the pre-Bötzinger complex stops inspiratory rhythm and impairs output in neonatal mice

    Xueying Wang et al.
    Laser-ablating neurons of a single genetic class reveals that Dbx1-derived interneurons comprise core respiratory rhythmogenic and premotor circuits and provides quantitative cellular parameters that govern network functionality
    1. Neuroscience

    Breathing: CO2 in the spotlight

    Luis R Hernandez-Miranda, Carmen Birchmeier
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    1. Neuroscience

    Opioids modulate an emergent rhythmogenic process to depress breathing

    Xiaolu Sun et al.
    Inspiratory rhythmogenesis is mediated by an emergent mechanism independent of bursts associated with motor output and is modulated by opioids, pointing to strategies for ameliorating opioid-induced respiratory depression.

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