254 results found
    1. Structural Biology and Molecular Biophysics

    Protein denaturation at the air-water interface and how to prevent it

    Edoardo D'Imprima et al.
    Hydrophilized graphene prevents protein denaturation at the air-water interface.
    1. Ecology

    Sexual selection gradients change over time in a simultaneous hermaphrodite

    Jeroen NA Hoffer et al.
    The quantification of sexual selection reveals that it is important to consider the chosen time frame of measurement as well as the sexual system.
    1. Developmental Biology

    Longevity is impacted by growth hormone action during early postnatal period

    Liou Y Sun et al.
    Transient hormonal alterations during early critical developmental periods can have a crucial and long-lasting effect on lifespan in mice.
    1. Developmental Biology

    A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

    Meng Amy Li et al.
    A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.
    1. Stem Cells and Regenerative Medicine

    Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

    Wenxuan Liu et al.
    Building on previous work (Liu et al., 2015), it is shown that depletion or rescue of adult skeletal muscle stem cells is sufficient to induce or attenuate age-associated neuromuscular junction deterioration respectively.
    1. Cell Biology

    The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

    Wenbao Hu et al.
    XIAP/TRIP-Br1-mediated degradation of multiple adenylyl cyclase isoforms is a previously unrecognised general mechanism for controlling adenylyl cyclase expression and the homeostasis of cAMP signalling.
    1. Cancer Biology

    Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

    Kashyap Dave et al.
    A tumor-specific regulatory region has been identified upstream of the Myc oncogene.
    1. Cancer Biology
    2. Human Biology and Medicine

    BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis

    Naoya Sakamoto et al.
    Genetic analyses reveal how CDX2 and BRAF defects seen in serrated colorectal cancer (CRCs), a poor prognosis CRC subset, cooperate in tumorigenesis in humans and in a mouse cancer model.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding

    Jixin Cui et al.
    Fam20A, a pseudokinase involved in the formation of tooth enamel, binds ATP in an unexpected orientation.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome

    An Van den Bossche et al.
    A bacteriophage remodels the RNA metabolism machinery of a bacterial host to sequentially clear host transcripts and then stabilize the viral RNA.

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