736 results found
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Lactoferricins impair the cytosolic membrane of Escherichia coli within a few seconds and accumulate inside the cell

    Enrico F Semeraro, Lisa Marx ... Georg Pabst
    The damage of the bacterial cell envelope is found to be only a secondary effect of the antimicrobial activity of lactoferricin derivatives.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cells

    Hourinaz Behesti, Arif Kocabas ... Mary E Hatten
    Human pluripotent stem cell modeling of the ATOH1 lineage identifies a temporal shift in the expression of key transcriptional regulators in the developing human cerebellum, this molecular divergence may drive the protracted development of the human cerebellum compared to rodents.
    1. Neuroscience

    Disordered breathing in a mouse model of Dravet syndrome

    Fu-Shan Kuo, Colin M Cleary ... Daniel K Mulkey
    Expression of a Dravet syndrome-associated mutation in inhibitory neurons disrupts activity of brainstem respiratory neurons and diminishes respiratory behavior in conjunction with seizures and premature death.
    1. Medicine

    Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies

    Sami Fawaz, Severine Marti ... Thierry Couffinhal
    If CHIP and mLOY do not significantly contribute to inflammation, atherosclerosis or myocardial infarction risk independently, CHIP may increase the risk of MI in men who do not carry mLOY.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Chromatin signature of widespread monoallelic expression

    Anwesha Nag, Virginia Savova ... Alexander A Gimelbrant
    Active and repressive chromatin marks, asymmetrically distributed between alleles, distinguish gene bodies subject to epigenetically controlled monoallelic expression on autosomes in human cells.
    1. Ecology

    Sexual selection gradients change over time in a simultaneous hermaphrodite

    Jeroen NA Hoffer, Janine Mariën ... Joris M Koene
    The quantification of sexual selection reveals that it is important to consider the chosen time frame of measurement as well as the sexual system.
    1. Biochemistry and Chemical Biology

    Decoding m6Am by simultaneous transcription-start mapping and methylation quantification

    Jianheng Fox Liu, Ben R Hawley ... Samie R Jaffrey
    Revised
    Reviewed Preprint v2
    Updated
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    • Compelling
    1. Neuroscience

    Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease

    Osman Shabir, Ben Pendry ... Jason Berwick
    Mice modelling atherosclerosis show neurovascular breakdown in the cortex compared to healthy controls, and inducing atherosclerosis in mice modelling Alzheimer's disease increases the number of amyloid plaques in the hippocampus.
    1. Cell Biology
    2. Developmental Biology

    Quantitative mapping of dense microtubule arrays in mammalian neurons

    Eugene A Katrukha, Daphne Jurriens ... Lukas C Kapitein
    Quantitative super-resolution light microscopy reveals the relative abundance and three-dimensional organization of different microtubule subsets within dendrites of mammalian neurons.

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