192 results found
    1. Genetics and Genomics
    2. Cancer Biology

    Early Diagnosis and Prognostic Prediction of Colorectal Cancer through Plasma Methylation Regions

    Lingqin Zhu, Lang Yang ... Jianqiu Sheng
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cancer Biology

    Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in FGFR2-amplified gastric cancer

    Yue Zhang, Hanbing Wang ... Jia Wei
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease

    Angel D'Oliviera, Xuhang Dai ... Jeffrey S Mugridge
    The SARS-CoV-2 main protease specifically cleaves a conserved sequence in the human tRNA modifying enzyme TRMT1, resulting in reduced tRNA binding and the complete loss of TRMT1-mediated tRNA methyltransferase activity.
    1. Microbiology and Infectious Disease

    An unusual trafficking domain in MSRP6 defines a complex needed for Maurer’s clefts anchoring and maintenance in P. falciparum infected red blood cells

    Alexandra Blancke Soares, Jan Stäcker ... Tobias Spielmann
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    Genome concentration limits cell growth and modulates proteome composition in Escherichia coli

    Jarno Mäkelä, Alexandros Papagiannakis ... Christine Jacobs-Wagner
    Genome dilution limits cell growth by modulating the activities, rather than the concentrations, of RNA polymerases and ribosomes, and is accompanied by changes in proteome composition.
    1. Stem Cells and Regenerative Medicine

    Rejuvenating aged osteoprogenitors for bone repair

    Joshua Reeves, Pierre Tournier ... Shukry J Habib
    Short-term interventions, including intermittent fasting, boosting cellular energy, and promoting beneficial gut bacteria, rejuvenate osteoprogenitors in aged animals and, when combined with localized Wnt, restore youthful bone healing.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Effects of residue substitutions on the cellular abundance of proteins

    Thea K Schulze, Kresten Lindorff-Larsen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics

    Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings

    Shek Man Chim, Kristen Howell ... Regeneron Genetics Center
    Loss of the Zinc transporter SLC39A5 protects from obesity-driven hyperglycemia and liver pathology.
    1. Ecology
    2. Evolutionary Biology

    First evidence for the evolution of host manipulation by tumors during the long-term vertical transmission of tumor cells in Hydra oligactis

    Justine Boutry, Océane Rieu ... Frédéric Thomas
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    A system for functional studies of the major virulence factor of malaria parasites

    Jakob Cronshagen, Johannes Allweier ... Tobias Spielmann
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
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