1,759 results found
  1. Cutting Edge: Towards PubMed 2.0

    Nicolas Fiorini et al.
    Staff from the National Center for Biotechnology Information in the US describe recent improvements to the PubMed search engine and outline plans for the future, including a new experimental site called PubMed Labs.
    1. Stem Cells and Regenerative Medicine

    Distinct SoxB1 networks are required for naïve and primed pluripotency

    Andrea Corsinotti et al.
    Genetic manipulations show that endogenous transcription factors of the SoxB1 class act redundantly to maintain primed pluripotency and reveal differential effects on transitions between pluripotent and differentiation states.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis

    Daniel M Cohen et al.
    The transcription factor C/EBPβ binds to different DNA sequences depending on whether it binds to ATF4, which enables C/EBPβ to conduct diverse transcriptional programs during adipocyte differentiation by exploiting an expanded motif repertoire.
    1. Cell Biology
    2. Developmental Biology

    Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

    Leah C Biggs et al.
    The hair follicle dermal condensate is populated via migration, and the cells exhibit early changes in cell shape and cell cycle status; Fgf20 primes these cellular and molecular events.
    1. Biochemistry and Chemical Biology
    2. Human Biology and Medicine

    The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition

    Jeremy L Praissman et al.
    Disruption of the LG domain-binding phospho-ribitol-containing O-mannose structures on α-dystroglycan results in congenital muscular dystrophy.
  2. Scientific Publishing: Launching eLife, Part 1

    Randy Schekman et al.
    The new open-access journal eLife has launched, making its first content available in PubMed Central. In addition to publishing science of the highest quality, the journal aims to improve both the peer-review process and the presentation of new research results.
    Editorial
    Available as:
    • HTML
    • PDF
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Helical jackknives control the gates of the double-pore K+ uptake system KtrAB

    Marina Diskowski et al.
    The K(+) uptake system KtrAB is controlled by an allosteric mechanism entirely new for membrane channels, which operates the channel gate over a 35 Å distance.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development

    Jan J Zylicz et al.
    Silencing of gene regulatory elements by modifications of DNA-bound proteins promotes the progression of early mouse development.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Tracing a protein’s folding pathway over evolutionary time using ancestral sequence reconstruction and hydrogen exchange

    Shion An Lim et al.
    Pulsed-labeling hydrogen exchange on the ribonuclease H family show that the major folding intermediate is conserved over three billion years of evolution, but the path leading to this intermediate varies.

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