2,966 results found
    1. Neuroscience

    Capturing the temporal evolution of choice across prefrontal cortex

    Laurence T Hunt et al.
    Experiments in macaques and humans reveal time-varying changes in prefrontal cortex activity that occur during decisions based on costs and benefits.
    1. Microbiology and Infectious Disease

    Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii

    Alex Hunt et al.
    Partially overlapping functions of a limited subset of actin binding proteins allow the parasite Toxoplasma gondii to achieve actin regulation required for complex cellular processes.
    1. Neuroscience

    Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice

    Sean E Cavanagh et al.
    Variability in individual neurons' temporal receptive fields of integration is found to explain the heterogeneity of neuronal responses observed in prefrontal cortex during reward-guided decision making.
    1. Microbiology and Infectious Disease

    Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration

    Malgorzata Broncel et al.
    Myristoylation of a secreted protein, identified in a global myristoylation analysis of the eukaryotic parasite Toxoplasma gondii, is important for host cell invasion.
    1. Ecology

    Mummified baboons reveal the far reach of early Egyptian mariners

    Nathaniel J Dominy et al.
    The fabled land of Punt is mapped for the first time using quantitative methods from the disciplines of primatology, geochemistry, and geography.
    1. Microbiology and Infectious Disease

    Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis

    Aleksandra Agapova et al.
    Metabolomics and stable isotope labelling studies of virulent Mycobacterium tuberculosis reveal a de-centralised metabolic network able to utilise various amino acids as nitrogen sources to a better extent than ammonium.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2

    Devanshi Jain et al.
    The mouse gene Ythdc2 exemplifies an evolutionarily ancient family of crucial regulators of the transition from germline stem cell divisions to meiosis.
    1. Microbiology and Infectious Disease

    Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir

    Jason Neidleman et al.
    An in-depth view of the in vivo blood and tissue HIV reservoir is presented highlighting shared phenotypic features between individuals, thus enabling marked ex vivo enrichment of replication-competent latent cells.
    1. Genetics and Genomics

    Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

    Matthias Thurner et al.
    Human pancreatic islet high-resolution chromatin state maps generated from DNA methylation, open chromatin and ChIP-seq mark data facilitate the characterisation of regulatory mechanisms at type 2 diabetes genome-wide association study loci.
    1. Neuroscience

    Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice

    Yu Takagi et al.
    Adaptation along multiple task-axes reveals choice traces at millisecond resolution in non-invasive recordings from human premotor cortex and provides evidence that theories of top-down control hold even after extensive experience.

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