346 results found
    1. Neuroscience

    Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours

    Laura D Knogler et al.
    Purkinje cells of the cerebellum, a conserved vertebrate brain region important for sensorimotor integration, receive sensory and motor information from distinct input streams and are functionally clustered into modules reflecting the larval zebrafish's behavioral repertoire.
    1. Neuroscience

    Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity

    Hannah L Payne et al.
    Patterned optogenetic stimulation and analysis of neural activity provide convergent evidence that cerebellar Purkinje cells drive eye movements with a rapid rate code, without an additional contribution of spike irregularity.
    1. Neuroscience

    Potentiation of cerebellar Purkinje cells facilitates whisker reflex adaptation through increased simple spike activity

    Vincenzo Romano et al.
    Physiological and behavioral analyses show that expression of cerebellar whisker learning can be mediated by increased simple spike activity, depending on LTP induction at parallel fiber to Purkinje cell synapses.
    1. Neuroscience

    TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells

    Bin Wu et al.
    Purkinje cells feature molecular heterogeneity that introduces differentiation in physiological properties between zebrin-identified cerebellar modules and thereby underlies the differential control on sensorimotor integration.
    1. Neuroscience

    Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo

    Jui-Yi Hsieh et al.
    Electrophysiological analysis and imaging in live zebrafish reveal that infant- and adult-onset SCA13 mutations have distinct effects on the electrical activity, development, and survival of cerebellar Purkinje cells.
    1. Neuroscience

    Neural Circuits: All Purkinje cells are not created equal

    Catarina Albergaria, Megan R Carey
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    1. Neuroscience

    Cerebellar Purkinje cell activity modulates aggressive behavior

    Skyler L Jackman et al.
    Optogenetic control of Purkinje cells in the cerebellar vermis enables bidirectional control of aggression.
    1. Neuroscience

    Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements

    Michael A Gaffield et al.
    In behaving mice, inhibition from molecular layer interneurons attenuates excitation of Purkinje cells by parallel fibers and suppresses their ability to enhance climbing fiber-triggered dendritic Ca2+ responses.
    1. Neuroscience

    Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation

    Amanda M Brown et al.
    Genetic, pharmacologic, and optogenetic manipulations demonstrate that Purkinje cells can trigger and propagate the signals for tremor.
    1. Neuroscience

    Coding of stimulus strength via analog calcium signals in Purkinje cell dendrites of awake mice

    Farzaneh Najafi et al.
    Sensory-driven calcium spikes in Purkinje cells are not binary; instead, they are graded and can provide information about the strength of a periocular airpuff stimulus known to drive learning.

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