Simultaneous voltage and calcium two-photon imaging of Purkinje neuron dendrites in awake mice reveals multiple interplaying mechanisms underlying sensory-evoked dendritic coincidence detection of parallel fiber and climbing fiber input.

In vivo recordings in unanesthetized zebrafish larvae show that Purkinje neurons have two stable membrane potential states and that climbing fiber inputs can toggle them to up states during motor episodes.

The N-terminus of the FGF14b isoform promotes the inactivation of voltage-gated Na⁺ channels to regulate the resurgent Na⁺ channel current needed for high frequency action potentials.

Injury at birth induces immature neurons to divide and regenerate cerebellar Purkinje cells in a time-dependent manner.

Cerebellar Purkinje neurons use a multiplexed simple spike code combining synchrony/spike time and firing rate, with each component encoding distinct information about movements such as motion onset timing and kinematics.

The first born excitatory cerebellar nuclei neurons influence the survival of their Purkinje cell partners which stimulate the expansion of granule cells and interneurons to produce functional local circuits.

Intersectional genetics show that excitatory neurons are essential for the functional and anatomical maturation of cerebellar circuits in mice.

5-Hydroxymethylcytosine-mediated active DNA demethylation occurs in postmitotic neurons, and is required for their terminal differentiation and function.

Signaling at the primary cilium is important to sustain the morphology, connectivity, and survival of a key neural population within the brain.

A protein that is a building block of intercellular bridges between neurons promotes their ability to grow dendrites and make synapses.