1,108 results found
    1. Neuroscience

    Functional effects of distinct innervation styles of pyramidal cells by fast spiking cortical interneurons

    Yoshiyuki Kubota, Satoru Kondo ... Yasuo Kawaguchi
    Cortical interneurons inhibit pyramidal cells to a greater degree when they form synapses with the pyramidal cell body than when they form synapses with dendrites.
    1. Neuroscience

    FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory

    Kirsty Sawicka, Caryn R Hale ... Robert B Darnell
    Identifying FMRP-bound mRNAs in hippocampal CA1 pyramidal neurons reveals cell-type specific regulation of autism-candidate and circadian mRNAs and FMRP-mediated control of memory across the circadian cycle.
    1. Neuroscience

    Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell

    Konstantinos-Evangelos Petousakis, Jiyoung Park ... Panayiota Poirazi
    Apical and basal dendrites contribute differently to single-neuron orientation selectivity, highlighting the impact of feedforward and feedback signal interactions.
    1. Neuroscience

    Cell-type specific innervation of cortical pyramidal cells at their apical dendrites

    Ali Karimi, Jan Odenthal ... Moritz Helmstaedter
    The composition of inhibitory and excitatory synaptic inputs to the apical dendrites of pyramidal cells in mouse cortex is specific to the type of pyramidal cells.
    1. Neuroscience

    Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors

    Prerana Shrestha, Awni Mousa, Nathaniel Heintz
    The well-established link between stress and depression could be due to the activity of a population of cells in prefrontal cortex that express a gene mutated in the rare disorder Wolfram syndrome.
    1. Neuroscience

    Dendritic branch structure compartmentalizes voltage-dependent calcium influx in cortical layer 2/3 pyramidal cells

    Andrew T Landau, Pojeong Park ... Bernardo L Sabatini
    Elaborate dendritic branch patterns lead to a local and branch-specific reduction in impedance, which attenuates back-propagating action potentials and limits voltage-gated calcium influx.
    1. Neuroscience

    Cholinergic modulation shifts the response of CA1 pyramidal cells to depolarizing ramps via TRPM4 channels with potential implications for place field firing

    Crescent L Combe, Carol M Upchurch ... Sonia Gasparini
    A nonspecific cation current mediated by TRPM4 channels is a major contributor to the increase in excitability induced by cholinergic modulation in hippocampal CA1 pyramidal neurons, which are thought to play an important role in episodic memory.
    1. Neuroscience

    CA1 pyramidal cell diversity is rooted in the time of neurogenesis

    Davide Cavalieri, Alexandra Angelova ... Rosa Cossart
    Embryonic birthdate is a crucial determinant of heterogeneity among CA1 principal neurons, which include a previously overlooked subpopulation of pioneer neurons.
    1. Neuroscience

    Distinct dendritic Ca2+ spike forms produce opposing input-output transformations in rat CA3 pyramidal cells

    Ádám Magó, Noémi Kis ... Judit K Makara
    Dendritic patch-clamp recordings combined with two-photon imaging and glutamate uncaging reveal two types of regenerative calcium spikes in the dendrites of CA3 pyramidal neurons from rat hippocampus.
    1. Neuroscience

    Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells

    Katalin Kerti-Szigeti, Zoltan Nusser
    All perisomatic GABAergic synpases on hippocampal pyramidal cells have a similar GABAA receptor subunit composition.

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