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Page 3 of 295
    1. Biochemistry and Chemical Biology

    Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria

    Erica N Thomas, Kyusik Q Kim ... Hani S Zaher
    Alkylation stress modify mRNAs and results in translation arrest, which activates the ribosome-rescue pathway of trans translation in bacteria.
    1. Epidemiology and Global Health

    The global burden of yellow fever

    Katy AM Gaythorpe, Arran Hamlet ... Neil Ferguson
    Yellow fever, a potentially deadly viral hemorrhagic fever, causes up to 82,000 deaths annually worldwide, and mass vaccination activities have reduced the burden by 47% in Africa.
    1. Structural Biology and Molecular Biophysics

    Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state

    Abhilash Padavannil, Anjaneyulu Murari ... James A Letts
    Molecular structure of mitochondrial complex I from Drosophila melanogaster reveals a structural element not seen in other organisms to date that may regulate the transition between an off-pathway resting state and the active state of the complex.
    1. Medicine

    Modulation of fracture healing by the transient accumulation of senescent cells

    Dominik Saul, David G Monroe ... Sundeep Khosla
    Senescent cells accumulate in the fracture callus and a reduction in the number of these cells accelerates fracture healing in mice.
    1. Neuroscience

    Heterogeneous side effects of cortical inactivation in behaving animals

    Ariana R Andrei, Samantha Debes ... Valentin Dragoi
    Focal optogenetic inactivation of cortex induces complex changes in neural responses outside the targeted area that can influence behavioral performance.
    1. Developmental Biology

    The glycosphingolipid MacCer promotes synaptic bouton formation in Drosophila by interacting with Wnt

    Yan Huang, Sheng Huang ... Yong Q Zhang
    Multiple independent analyses reveal that a specific membrane lipid directly interacts with the signalling protein Wingless to promote synapse growth at the Drosophila neuromuscular junctions.
    1. Neuroscience

    One bout of neonatal inflammation impairs adult respiratory motor plasticity in male and female rats

    Austin D Hocker, Sarah A Beyeler ... Adrianne G Huxtable
    A single neonatal inflammatory event induces long-term impairments in two forms of adult respiratory motor plasticity, an important aspect of the control of breathing for compensation after injury or disease.
    1. Cancer Biology

    Proteogenomic analysis of air-pollution-associated lung cancer reveals prevention and therapeutic opportunities

    Honglei Zhang, Chao Liu ... Gaofeng Li
    MAD1 and TPRN were identified as novel potential therapeutic targets of lung adenocarcinoma in female never-smokers from the Xuanwei area.
    1. Genetics and Genomics

    Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization

    Mark Gormley, Tom Dudding ... Caroline Bull
    Mendelian randomization suggests the possibility that the observational effects of obesity and related metabolic traits in head and neck cancer risk are overestimated.
    1. Evolutionary Biology
    2. Neuroscience

    Whole-brain comparison of rodent and human brains using spatial transcriptomics

    Antoine Beauchamp, Yohan Yee ... Jason P Lerch
    A novel machine learning approach improves quantitative comparisons of mouse and human brains using spatial transcriptomics data sets.