675 results found
    1. Structural Biology and Molecular Biophysics

    Geometry of antiparallel microtubule bundles regulates relative sliding and stalling by PRC1 and Kif4A

    Sithara Wijeratne, Radhika Subramanian
    Geometrical features of microtubule arrays regulate the collective activity of motor and non-motor proteins.
    1. Computational and Systems Biology

    Quantifying how post-transcriptional noise and gene copy number variation bias transcriptional parameter inference from mRNA distributions

    Xiaoming Fu, Heta P Patel ... Ramon Grima
    A combined experimental and modeling approach provides insight into potential biases when inferring transcription rates from static mRNA distributions, and shows that correcting for cell-cycle phase and post-transcriptional noise provides rates that agree with live-cell transcription measurements.
    1. Neuroscience

    Enhancing precision in human neuroscience

    Stephan Nebe, Mario Reutter ... Gordon B Feld
    Measurement precision offers a comprehensive perspective on good scientific practices to improve reproducibility of research results by providing means to optimize design and analysis parameters (e.g. sample size, trial count, or sample heterogeneity) in accordance with the researcher’s goals.
    1. Neuroscience

    Prefrontal-amygdalar oscillations related to social behavior in mice

    Nahoko Kuga, Reimi Abe ... Takuya Sasaki
    The dorsal medial prefrontal cortex and basolateral amygdala exhibit social behavior-relevant neuronal oscillations, representing unified pathophysiological mechanisms underlying social behavioral deficits.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Fucosylation and protein glycosylation create functional receptors for cholera toxin

    Amberlyn M Wands, Akiko Fujita ... Jennifer J Kohler
    Cholera intoxication of human colonic epithelial cells is dependent on recognition of protein glycosylation and fucosylation, not exclusively on ganglioside recognition as proposed previously.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Mechanically transduced immunosorbent assay to measure protein-protein interactions

    Christopher J Petell, Kathyrn Randene ... Joshua P Steimel
    METRIS is a method that reports a mechanical readout of protein-protein interactions and due to its unique properties, it will allow many protein-protein interactions to be quantitatively measured easily that are currently laborious to measure with conventional methods.
    1. Neuroscience

    A single pair of pharyngeal neurons functions as a commander to reject high salt in Drosophila melanogaster

    Jiun Sang, Subash Dhakal ... Youngseok Lee
    Fruit flies have special neurons in their pharynx with ionotropic receptors to prevent consuming too much salt, which was confirmed using a variety of behavioral and physiological assays.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix

    David Barneda, Joan Planas-Iglesias ... Mark Christian
    An interaction between the brown fat protein CIDEA and the phospholipid phosphatidic acid is vital for the expansion of intracellular lipid droplets for energy storage.
    1. Chromosomes and Gene Expression

    Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization

    Pavan Choppakatla, Bastiaan Dekker ... Hironori Funabiki
    Linker histone H1.8 shapes mitotic chromosomes by tuning the number and size of condensin-dependent DNA loops and suppressing condensin and DNA topoisomerase II-dependent individualization.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Remodeling of skeletal muscle myosin metabolic states in hibernating mammals

    Christopher TA Lewis, Elise G Melhedegaard ... Julien Ochala
    During hibernation, animals remodel the structure of their relaxed muscle via a protein called myosin and this enables vast temperature changes.

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