127 results found
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

    Susan Martin, Jessica Tyrrell ... Hanieh Yaghootkar
    Using genetics, it is possible to uncouple higher adiposity from its adverse metabolic effects and show that some obesity-associated conditions may benefit from treating the metabolic effects alone, whilst others may benefit more from weight loss.
    1. Medicine
    2. Neuroscience

    Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer’s disease and neurodegeneration stratified by sex

    Irene Cumplido-Mayoral, Marina García-Prat ... OASIS study
    Brain-Age delta is a non-invasive marker of biological brain aging that is sensitive to the presence of risk factors and altered biomarkers of Alzheimer's disease in non-demented individuals.
    1. Neuroscience

    State-dependent geometry of population activity in rat auditory cortex

    Dmitry Kobak, Jose L Pardo-Vazquez ... Alfonso Renart
    Representation of sound lateralisation and intensity by neural population in the rat auditory cortex strongly depends on the brain state suggesting that the neural tuning to lateralisation is not hard-wired.
    1. Evolutionary Biology

    A multispecies coalescent model for quantitative traits

    Fábio K Mendes, Jesualdo A Fuentes-González ... Matthew W Hahn
    A model for evolutionary inferences at both micro- and macroevolutionary scales is proposed and evaluated theoretically and through simulations.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Inversions Can Accumulate Balanced Sexual Antagonism: Evidence from Simulations and Drosophila Experiments

    Christopher S McAllester, John E Pool
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Incomplete
    1. Neuroscience

    Quantitative modeling of the emergence of macroscopic grid-like representations

    Ikhwan Bin Khalid, Eric T Reifenstein ... Richard Kempter
    A computational study quantifies how macroscopic grid-like representations may emerge in the human brain using different hypotheses and navigation patterns, indicating the need to further characterize properties of grid cells.
    1. Neuroscience

    Subpopulations of neurons in lOFC encode previous and current rewards at time of choice

    David L Hocker, Carlos D Brody ... Christine M Constantinople
    A distinct subpopulation of neurons in the rat orbitofrontal cortex encodes reward history at the time of choice, providing a potential neural substrate by which reward history may influence decisions.
    1. Neuroscience

    Effects of noise and metabolic cost on cortical task representations

    Jake Patrick Stroud, Michal Wojcik ... Mate Lengyel
    The dynamical solutions exhibited by task-optimized recurrent neural networks, and their similarity to prefrontal cortex dynamics, depends strongly on the strength of neural noise and metabolic cost imposed during training.
    1. Neuroscience

    Sensory input-dependent gain modulation of the optokinetic nystagmus by mid-infrared stimulation in pigeons

    Tong Xiao, Kaijie Wu ... Yan Yang
    Simultaneous stimulation and recording in awake-behaving pigeons showed that mid-infrared stimulation, as a promising neuromodulation approach, could facilitate or suppress neuronal firing activity depending on its ongoing sensory responsiveness levels, and cause reversible and gain modulation on sensorimotor behavior.
    1. Neuroscience
    2. Computational and Systems Biology

    Adaptive Integration of Perceptual and Reward Information in an Uncertain World

    Prashanti Ganesh, Radoslaw M Cichy ... Rasmus Bruckner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid

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