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    1. Developmental Biology
    2. Neuroscience

    Spatiotemporal tissue maturation of thalamocortical pathways in the human fetal brain

    Siân Wilson, Maximilian Pietsch ... Tomoki Arichi
    Using fetal magnetic resonance imaging (MRI), maturational changes in tissue microstructure can be derived using diffusion MRI which provide new insight into the fundamental neurobiological transitions occurring within the emerging thalamocortical white matter pathways.
    1. Computational and Systems Biology
    2. Neuroscience

    Circadian Rhythm: How neurons adjust to diurnality

    Gabriele Andreatta, Charles N Allen
    Being active during the day requires a slow-closing ion channel that dampens the activity of neurons in a specific area of the brain.
    Version of Record
    Insight
    1. Evolutionary Biology
    2. Genetics and Genomics

    Admixture of evolutionary rates across a butterfly hybrid zone

    Tianzhu Xiong, Xueyan Li ... James Mallet
    Genetic barriers to gene flow maintain divergent linked substitution rates in hybridization.
    1. Cell Biology
    2. Neuroscience

    RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation

    Kei Nakayama, Rie Ohashi ... Nobuyuki Shiina
    The formation of long-term memory in mice requires an element of RNA granules that localizes messenger RNAs to dendrites.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio

    Chase A Weidmann, Chen Qiu ... Aaron C Goldstrohm
    Crystal structures of Nanos bound to Pumilio and target RNAs demonstrate how Nanos forms a molecular clamp to alter Pumilio RNA regulation and specificity in embryonic development and germline maintenance.
    1. Neuroscience

    Location- and feature-based selection histories make independent, qualitatively distinct contributions to urgent visuomotor performance

    Emily E Oor, Emilio Salinas, Terrence R Stanford
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Evolutionary Biology

    Multifactorial processes underlie parallel opsin loss in neotropical bats

    Alexa Sadier, Kalina TJ Davies ... Karen E Sears
    Parallel losses of short-wave light sensitivity in diverse bats occurred through independent changes at multiple steps in the conversion of genotype into functional phenotype, including pre-, during, and post-transcription.
    1. Genetics and Genomics
    2. Plant Biology

    Principles of mRNA targeting via the Arabidopsis m6A-binding protein ECT2

    Laura Arribas-Hernández, Sarah Rennie ... Peter Brodersen
    The Arabidopsis N6-methyladenosine (m6A)-binding protein ECT2 binds to m6A in the canonical RR[m6A]CH motif, not a plant-specific motif as previously thought, and its intrinsically disordered region contributes to mRNA binding via contacts with U-rich motifs.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

    Mahmoud M Elguindy, Florian Kopp ... Joshua T Mendell
    Interaction with PUMILIO is essential for maintenance of genomic stability by the cytoplasmic long noncoding RNA NORAD, whereas binding to RBMX is dispensable for this function.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Engineering a conserved RNA regulatory protein repurposes its biological function in vivo

    Vandita D Bhat, Kathleen L McCann ... Zachary T Campbell
    Motif length plays a critical role in the specification of biological function within a conserved family of RNA-binding proteins.