Using fetal magnetic resonance imaging (MRI), maturational changes in tissue microstructure can be derived using diffusion MRI which provide new insight into the fundamental neurobiological transitions occurring within the emerging thalamocortical white matter pathways.
Crystal structures of Nanos bound to Pumilio and target RNAs demonstrate how Nanos forms a molecular clamp to alter Pumilio RNA regulation and specificity in embryonic development and germline maintenance.
Parallel losses of short-wave light sensitivity in diverse bats occurred through independent changes at multiple steps in the conversion of genotype into functional phenotype, including pre-, during, and post-transcription.
Laura Arribas-Hernández, Sarah Rennie ... Peter Brodersen
The Arabidopsis N6-methyladenosine (m6A)-binding protein ECT2 binds to m6A in the canonical RR[m6A]CH motif, not a plant-specific motif as previously thought, and its intrinsically disordered region contributes to mRNA binding via contacts with U-rich motifs.
Mahmoud M Elguindy, Florian Kopp ... Joshua T Mendell
Interaction with PUMILIO is essential for maintenance of genomic stability by the cytoplasmic long noncoding RNA NORAD, whereas binding to RBMX is dispensable for this function.