Pup-On-target for Small molecule Target Identification Technology, POST-IT, is a revolutionary tool for accurately identifying protein targets of bioactive molecules in living cells and organisms, successfully identifying SEPHS2 and VPS37C as targets for dasatinib and hydroxychloroquine, respectively.

rhPTH(1-34) and dimeric ^R25CPTH(1-34) significantly promoted bone regeneration and titanium implant osseointegration in an osteoporotic beagle model.

Long-latency reflexes flexibly encode future goals during sequential reaching movements, reflecting the parallel and task-dependent processing of a sequence of goals in circuits that mediate fast feedback control.

Dermal preadipocytes produce T cell chemokines in response to IFNγ, driving the recruitment and activation of type 1 effector T cells in allergic contact dermatitis.

All-atom molecular dynamics simulations of an αβ T-cell receptor complexed with the major histocompatibility complex molecule presenting wild-type or mutant antigenic peptides reveal how it uses conserved framework motion to discriminate antigens by leveraging physiological force applied during immune surveillance.