200 results found
    1. Chromosomes and Gene Expression
    2. Biochemistry and Chemical Biology

    Cooperative interactions facilitate stimulation of Rad51 by the Swi5-Sfr1 auxiliary factor complex

    Bilge Argunhan et al.
    The intrinsically disordered N-terminus of Sfr1 contains two Rad51 binding sites that facilitate Rad51 filament stabilization and ATPase stimulation by the Swi5-Sfr1 complex, leading to efficient Rad51-driven strand exchange.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors

    Negar Afshar et al.
    Although Rad51 is the central protein involved in recombinational DNA repair, multiple auxiliary factors potentiate its activity by binding to a single, evolutionarily conserved motif.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells

    Sarah R Hengel et al.
    Small molecule inhibitors identified in a biophysical high-throughout screening assay confirm the importance of the interaction between single-stranded DNA and the protein RAD52 for the survival of BRCA2-depleted cells.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Rad52-Rad51 association is essential to protect Rad51 filaments against Srs2, but facultative for filament formation

    Emilie Ma et al.
    The association of Rad52 with Rad51, while not critical for Rad51 filament formation, is crucial to protect Rad51 filaments from Srs2 translocase activity through the association of Rad52 with complete Rad51 filaments.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53

    Syafiq Abd Wahab, Dirk Remus
    The mechanism of Dbf4-dependent kinase (DDK) recruitment to replication origins and its regulation by the checkpoint have been identified.
    1. Chromosomes and Gene Expression

    Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

    Allison W McClure, John FX Diffley
    DNA replication fork rate in budding yeast is regulated in response to DNA damage by phosphorylation of two proteins, Mrc1 and Mcm10, by the Rad53 protein kinase.
    1. Chromosomes and Gene Expression

    Rdh54/Tid1 inhibits Rad51-Rad54-mediated D-loop formation and limits D-loop length

    Shanaya Shital Shah et al.
    The dsDNA-dependent motor protein Rdh54 antagonizes Rad51-Rad54-mediated D-loop formation during homologous recombination and restricts the length of D-loops.
    1. Chromosomes and Gene Expression

    Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner

    Juan Lafuente-Barquero et al.
    RNA does not form DNA:RNA hybrids in trans that compromise genome integrity.
    1. Chromosomes and Gene Expression

    The homologous recombination machinery modulates the formation of RNA–DNA hybrids and associated chromosome instability

    Lamia Wahba et al.
    When a protein involved in DNA repair malfunctions, it can anneal RNA molecules to DNA molecules, creating hybrids that increase the frequency of mutations in the DNA.
    1. Chromosomes and Gene Expression

    p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways

    Sunetra Roy et al.
    p53 suppresses genome instability by direct role at stalled replication forks for pathway regulation that explains transcription-independent p53 tumor-suppressor functions.

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