125 results found
    1. Neuroscience

    Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels

    Francesco Tomassoni-Ardori et al.
    RbFox1 upregulation modulates the expression of hundreds of genes but only dysregulation of the TrkB.T1 receptor isoform expression causes BDNF-dependent LTP impairments.
    1. Developmental Biology

    Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate

    Dasan Mary Cibi et al.
    The identification of the splicing code and all the required components of alternative splicing will be crucial for a comprehensive understanding of this process in the neural crest cell biology.
    1. Cell Biology

    Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow

    Patrick A Murphy et al.
    Transcriptome analysis reveals an alternative splicing program induced in the arterial endothelium under low-flow inflammatory conditions by platelet and macrophage recruitment and dependent upon the RNA-binding splice factor Rbfox2.
    1. Cancer Biology
    2. Cell Biology

    An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

    Ji Li et al.
    Splicing by QKI and RBFOX1 regulates the function of the actin-binding protein FLNB by creating an isoform frequently observed in human cancers that dictates tumor cell plasticity.
    1. Immunology and Inflammation

    Lys29-linkage of ASK1 by Skp1−Cullin 1−Fbxo21 ubiquitin ligase complex is required for antiviral innate response

    Zhou Yu et al.
    By joining the Skp1-Cul1-Rbx1 SCF complex, Fbxo21 interacts with ASK1 and mediates Lys29-linkage of ASK1, leading to type I IFN production.
    1. Computational and Systems Biology

    Point of View: Data science for the scientific life cycle

    Daphne Ezer, Kirstie Whitaker
    Each stage of the scientific life cycle stands to benefit from the introduction of data science techniques.
    1. Computational and Systems Biology

    Meta-Research: Incidences of problematic cell lines are lower in papers that use RRIDs to identify cell lines

    Zeljana Babic et al.
    The use of Research Resource Identifiers (RRIDs) improves the proper use of cell lines in the biomedical literature.
    1. Ecology
    2. Plant Biology
    Arabidopsis illustration

    The Natural History of Model Organisms: Planting molecular functions in an ecological context with Arabidopsis thaliana

    Ute Krämer
    Research in molecular ecology and evolution is increasingly utilizing the model plant Arabidopsis thaliana, placing a spotlight on its natural history.
    1. Developmental Biology
    Ciona intestinalis illustration

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.
    1. Ecology
    2. Evolutionary Biology
    Zebrafish illustration

    The Natural History of Model Organisms: Advancing biology through a deeper understanding of zebrafish ecology and evolution

    David M Parichy
    The zebrafish is a premier model organism for biomedical research, with a rich array of tools and genomic resources, and combining these with a fuller appreciation of wild zebrafish ecology could greatly extend its utility in biological research.

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