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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction

    Jan Hendrik van Weerd et al.
    Multiple variant transcriptional regulatory elements in >1 megabasepairs of noncoding DNA close to TBX3 affect gene expression and atrioventricular conduction system function in vivo.
    1. Computational and Systems Biology
    2. Neuroscience

    Blood transcriptome based biomarkers for human circadian phase

    Emma E Laing et al.
    An unbiased modelling approach shows that only a few blood transcriptome samples are required to accurately assess the human circadian melatonin phase, even during altered sleep schedules.
    1. Cell Biology
    2. Developmental Biology

    The exon junction complex regulates the splicing of cell polarity gene dlg1 to control Wingless signaling in development

    Min Liu et al.
    The exon junction complex regulates the cell polarity determinant Discs large 1, which acts independently from its role in cell polarity to protect Dishevelled protein from lysosomal degradation in Wingless/Wnt signaling.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer

    Sakari Vanharanta et al.
    Inactivation of a multifunctional RNA-binding protein can lead to the acquisition of pro-metastatic phenotypes, possibly by stabilizing large-scale transcriptomic changes that provide a selective advantage during cancer progression.
    1. Cancer Biology

    Protein phase separation and its role in tumorigenesis

    Shan Jiang et al.
    The current understanding of phase separation is summarized and its emerging roles in cancer are discussed in detail.
    1. Cell Biology

    Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1

    David F Moreno et al.
    Cells accumulate damaged proteins during aging and, by compromising the function of chaperones in folding newly synthesized G1 cyclins, proteostasis breakdown inhibits cell-cycle entry and drives yeast cells into senescence.
    1. Genetics and Genomics

    An incoherent feedforward loop facilitates adaptive tuning of gene expression

    Jungeui Hong et al.
    The architecture of a gene regulatory network determines the effect of evolutionary changes in transcription factor binding.
    1. Microbiology and Infectious Disease

    The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi’s sarcoma-associated herpesvirus

    Belinda Baquero-Perez et al.
    SND1 has m6A-reading ability and is essential for Kaposi's sarcoma-associated lytic replication.
    1. Stem Cells and Regenerative Medicine

    The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice

    Kerstin Schmidt et al.
    The H3K4 methyltransferase Setd1b is intrinsically required for hematopoietic stem and progenitor cell homeostasis and regulates lineage specification in mice.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Dissection of affinity captured LINE-1 macromolecular complexes

    Martin S Taylor et al.
    The range of molecular forms adopted by L1 retrotransposons reflect a tapestry of lifecycle-permissive and -restrictive host-parasite interactions occurring within cells.