97 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

    Mahmoud M Elguindy et al.
    Interaction with PUMILIO is essential for maintenance of genomic stability by the cytoplasmic long noncoding RNA NORAD, whereas binding to RBMX is dispensable for this function.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms

    Jiunn CN Fong et al.
    Biofilm matrix protein RbmA controls biofilm architecture through binary structural switching and exopolysaccharide binding.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation

    André Mourão et al.
    Interactions with Sm proteins can provide a way in which regulatory factors can modulate alternative splice site choices.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Biofilms: Flipping the switch

    Xavier Pierrat, Alexandre Persat
    A structural switch controls the architecture of Vibrio cholerae biofilms by mediating the interactions between two matrix components.
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    1. Cell Biology

    Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

    Craig A Nash et al.
    β-adrenergic receptors at the Golgi apparatus activate a local signaling pathway, not accessed by cell surface receptors, to drive cardiac hypertrophy and could represent a target for heart failure therapy.
    1. Developmental Biology

    Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate

    Dasan Mary Cibi et al.
    The identification of the splicing code and all the required components of alternative splicing will be crucial for a comprehensive understanding of this process in the neural crest cell biology.
    1. Neuroscience

    PARIS, an optogenetic method for functionally mapping gap junctions

    Ling Wu et al.
    As the first fully genetically encoded method, PARIS allows cell-specific, long-term, repeated measurements of gap junctional coupling with high spatiotemporal resolution, facilitating its study in both health and disease.
    1. Structural Biology and Molecular Biophysics

    Molecular basis of signaling specificity between GIRK channels and GPCRs

    Kouki K Touhara, Roderick MacKinnon
    A single kinetic step in the G protein activation cycle determines whether a G protein-coupled receptor activates G protein-gated K+ channels or not.
    1. Chromosomes and Gene Expression

    An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning

    Ingrid Ehrmann et al.
    Cell division by meiosis during sperm production depends on expression of an RNA-binding protein that prevents abnormal RNA-processing pathways.
    1. Human Biology and Medicine

    SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion

    Saumel Ahmadi et al.
    Loss of an amino acid transporter and tissue depletion of nitric oxide worsens the intestinal function of CF mice, a finding that potentially explains variation in disease severity amongst CF individuals.

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