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The new insights into the activation mechanism of Parkin E3 ligase could be useful for designing small-molecule activators against Parkinson’s disease.

The synaptic ribbon regulates calcium channel clustering and proper vesicle dynamics at cochlear inner hair cells to ensure precise sound encoding.

A model-based approach for modelling the immune control of viral dynamics is applied to quantify the effect of several SARS-CoV-2 vaccine platforms and to define mechanistic correlates of protection.

A new machine-learning toolbox unveils coevolutionary protein motifs related to structure, function, and phylogeny from sequence information only.

A muscle-derived Wnt signal promotes dendritic branching of somatosensory neurons in response to a concurrent deficiency in vitamins, minerals, and cholesterol.

A skewed B cell response in people living with HIV proceeds via an extrafollicular path and could result in reduced affinity B cell memory and antibody responses.

Transcription profiling of activated cells using Phospho-Trap, a new method for identifying activated cells, reveals a critical role for mTOR signaling in red blood cell development and the pathogenesis of anemia

Lamin B receptor may provide a long-sought model system enabling unprecedented studies of protein quality control in the nuclear envelope of mammalian cells.

A systematic review with multilevel modelling quantified the positive association between human antibodies to Anopheles salivary proteins with Anopheles-human biting rate and epidemiological measures of malaria transmission, highlighting their potential as a tool to measure vector exposure and malaria transmission.

The SCF-family of ubiquitin ligases regulates the key cancer proliferation node by controlling the degradation of RB-like tumor suppressor RBL2/p130.