1,464 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    RNA-guided assembly of Rev-RRE nuclear export complexes

    Yun Bai et al.
    Tertiary folding of the Rev-response element (RRE) in HIV RNA ensures the rapid formation of the Rev-RRE viral ribonucleoprotein particle via a two-step process.
    1. Chromosomes and Gene Expression

    Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages

    Dawn Z Eichenfield et al.
    Combinatorial signaling leads to transcription factor co-localization at Rev-erb sensitive enhancers, enabling a diversified cellular response to complex stimuli.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev–Rev response element complex

    Bhargavi Jayaraman et al.
    A pliable hydrophobic interface in the HIV-1 Rev protein enables assembly of diverse oligomeric structures, guided by the RRE scaffold present in HIV-1 mRNAs.
    1. Plant Biology

    A viral protein promotes host SAMS1 activity and ethylene production for the benefit of virus infection

    Shanshan Zhao et al.
    Rice dwarf virus Pns11 protein increases rice susceptibility to virus infection by enhancing OsSAMS1 enzymatic activity and ethylene production.
    1. Microbiology and Infectious Disease

    Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production

    MengJie Hu et al.
    RSV's unique ability to co-opt host cell mitochondria to facilitate viral infection reveals the RSV-mitochondrial interface as a viable target for therapeutic intervention.
    1. Epidemiology and Global Health

    Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions

    Oliver John Watson et al.
    The timing of surveillance for pfhrp2/3-deletions within a transmission season impacts estimates of the proportion of false-negative RDTs due to deletions, which may cause premature decisions to change RDT.
    1. Epidemiology and Global Health

    Genetic epidemiology of dengue viruses in phase III trials of the CYD tetravalent dengue vaccine and implications for efficacy

    Maia A Rabaa et al.
    In large vaccine trials conducted in dengue-endemic Asia and Latin America, the CYD-TDV tetravalent dengue vaccine shows limited variation in intra-serotype efficacy in the target population for vaccination (>9 years).
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA

    David S Booth et al.
    The nuclear export receptor Crm1 cooperatively binds its HIV Rev-RRE cargo as a dimer using a species-specific interface that supports viral replication by enhancing nuclear export of HIV RNA.

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