3,381 results found
    1. Structural Biology and Molecular Biophysics

    Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions

    Ben Sorum et al.
    In the CFTR chloride channel, ATP bound in the catalytic site promotes pore opening, whereas ATP bound in the non-catalytic site supports unidirectional conformational cycling by preventing pore closure without ATP hydrolysis in the catalytic site.
    1. Computational and Systems Biology
    2. Neuroscience

    Rats exhibit similar biases in foraging and intertemporal choice tasks

    Gary A Kane et al.
    In both foraging and intertemporal choice tasks, rats prefer immediate rewards to delayed rewards, and this preference can be explained by a form of hyperbolic discounting.
  1. Food for thought: an interview with Ana Domingos

    Ana Domingos of the Gulbenkian Science Institute in Portugal has forged a career learning why we like certain types of food. By looking at the reward system of the mouse brain, she has revealed pathways that explain why animals prefer sugar, and perhaps why it may factor so strongly in the Western diet.
    1. Human Biology and Medicine

    Point of View: Competency-based assessment for the training of PhD students and early-career scientists

    Michael F Verderame et al.
    A method to assess the training of scientists, based on a set of 10 core competencies, is proposed.
  2. Plain-language Summaries of Research: An inside guide to eLife digests

    Stuart RF King et al.
    After summarizing over 2,400 articles in plain language, the eLife Features team shares what it has learnt about writing and editing for a broad audience.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Point of View: Is cell size a spandrel?

    Ariel Amir
    Analysis of experiments on bacteria suggests that the dependence of cell size on growth rate is not an adaptation but a causal consequence of a regulatory mechanism that controls DNA replication.

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