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Anomalous expression of the testis protein ZNF165 in cancer cells promotes assembly of a neomorphic transcriptional complex that modulates transcription of TGFβ target genes to support tumor cell survival.

A new biophysical model enables the reconciliation of ultrastructural and tissue level measurements on parameters affecting intercellular communication, and provides novel functional insight into experimental findings.

The K(+) uptake system KtrAB is controlled by an allosteric mechanism entirely new for membrane channels, which operates the channel gate over a 35 Å distance.

A small molecule compound Dwn1, identified through high-throughput screening using Npas2 as the molecular target, enhances wound healing in a murine incisional wound model.

The application of real-time genomics by long-read nanopore sequencing to environmental samples creates a new trajectory for non-invasive genomics-based monitoring of critically endangered wildlife.

A new platform for imaging live Drosophila adults yields vivid movies of the midgut over prolonged time scales, opening the door to the real-time study of organ renewal dynamics in a near-native context.

The Real-Time Experimental Control with Graphical User Interface (REC-GUI) framework can facilitate cutting-edge neuroscience research by providing precise experimental control using high-level programming environments familiar to many experimentalists.

RecX effectively disrupts dynamic conformational changes in the RecA-ssDNA filament by stabilizing its inactive form.

A statistically principled approach developed to estimate phase of rhythmic signals in real-time shows robustness to multiple sources of error and also provides confidence criteria.

A live imaging and computational approach reveals feedback loops involving F-actin dynamics that regulate the NF-κB transcription factor RELA.