323 results found
  1. January 2015

    Episode 17: January 2015

    In this episode we hear about controlling sperm by optogenetics, hibernation, body clocks, enzyme structure, and a way to overcome stress-induced infertility.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular basis of outer kinetochore assembly on CENP-T

    Pim J Huis in 't Veld et al.
    The centromeric protein CENP-T assembles the microtubule-binding interface of kinetochores through direct recruitment of two Ndc80 complexes and indirect recruitment of a third one through the Mis12 complex.
    1. Microbiology and Infectious Disease

    Structural basis of host recognition and biofilm formation by Salmonella Saf pili

    Longhui Zeng et al.
    SafDAA-SafDAA structure and functional characterizations reveal a pili-mediated inter-cellular oligomerization mechanism for bacterial aggregation and biofilm formation in Salmonella enterica.
    1. Epidemiology and Global Health

    Effects of water, sanitation, handwashing, and nutritional interventions on telomere length among children in a cluster-randomized controlled trial in rural Bangladesh

    Audrie Lin et al.
    In a randomized controlled trial in rural Bangladesh, an intensive, combined water, sanitation, handwashing, and nutrition intervention delivered to compounds of newborn children increased telomere length attrition during their first year of life.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids

    Alexander Muir et al.
    TORC2-Ypk1 signaling upregulates flux through the sphingolipid pathway not only by increasing the supply of long-chain base precursors, but also by increasing their use in synthesizing complex sphingolipids.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

    Welkin H Pope et al.
    A continuum of genome relationships is discovered through comparative genomics of 627 sequenced mycobacteriophages isolated and characterized in an integrated research/education initiative.
    1. Biochemistry and Chemical Biology

    Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding

    Julia R Kardon et al.
    The mitochondrial protein unfoldase ClpX activates the first enzyme in heme biosynthesis, ALAS, by targeted unfolding that gates access of cofactor to the ALAS active site.
    1. Biochemistry and Chemical Biology

    Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis

    Byungchul Kim et al.
    Enterococci faecium encodes unique peptidoglycan composition and remodeling activity that activates host immunity.
    1. Neuroscience

    Cortico-hippocampal network connections support the multidimensional quality of episodic memory

    Rose A Cooper, Maureen Ritchey
    Enhanced hippocampal-cortical network communication during memory retrieval flexibly tracks the quality and content of memories for complex past events.
    1. Cancer Biology
    2. Human Biology and Medicine

    The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

    James D Joseph et al.
    GDC-0810 is a novel, orally bioavailable SERD that exhibits robust pre-clinical activity in models of ER+ breast cancer, including models of tamoxifen resistance, and those that express the ERα mutations, ER.Y537S and ER.D538G.

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