Synergistic interactions with PI(4,5)P2 and activated Rho1, which are enriched at the apical membrane of tubular organs, facilitate tight apical targeting of the formin Diaphanous.

Drosophila ZIP13 (Slc39a13), a presumed zinc importer, is responsible for iron delivery to the secretory pathway.

A systematic analysis of gene–gene dependencies using high-throughput imaging of cells detects causal and temporal relationships between genes.

Building on previous work (Muir et al., 2014), we validate the utility of a screen for new protein kinase substrates and define the underlying molecular basis of a new mechanism for responding to hypertonic conditions.

The key Target of Rapamycin Complex (TORC1) component Kog1 moves into bodies during glucose starvation to limit reactivation of the complex.

The evolutionarily conserved polarity protein Crumbs links the regulation of cytoskeleton dynamics and cell-cell adhesion with epithelial morphogenesis.

Identification of novel components and regulators of heterochromatin reveals a spatially complex and dynamic organization.

Functional recapitulation of a likely evolutionary gain in gene expression shows that two genes are sufficient to switch mesoderm cell internalization from stochastic cell ingression to coordinated epithelial invagination.

Calcium influx during acute cell stimulation triggers a global actin reset in mammalian cells, which is linked to plasma membrane repair and transcription and has implications for our understanding of cell migration, cancer, inflammation and cell stress response.

Spatially coordinated apical constriction occurs during Drosophila salivary gland invagination, but the salivary gland can form fully internalized and elongated tubes even when this process is completely blocked.