37 results found
    1. Cancer Biology
    2. Cell Biology

    Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

    Hao Zeng et al.
    Functional genomic screening reveals new synthetic lethality with and modes of resistance to epidermal growth factor receptor (EGFR) targeted therapy in EGFR-mutant human lung cancer.
    1. Cancer Biology
    2. Cell Biology

    Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling

    Benjamin L Ricca et al.
    In a 3D culture model of breast epithelium, application of a short-timescale compression to single malignant cells promotes the long-timescale development of polarized, growth-arrested structures.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα

    Ravi Kant et al.
    Hydrogen-Deuterium exchange experiments show that Ric-8A induces similar dynamic changes in the structure of Gα as G protein-coupled receptors, yet protects a larger surface of the nucleotide-binding Ras domain.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

    Welkin H Pope et al.
    A continuum of genome relationships is discovered through comparative genomics of 627 sequenced mycobacteriophages isolated and characterized in an integrated research/education initiative.
    1. Chromosomes and Gene Expression

    Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3

    Lianna Schwartz-Orbach et al.
    H3K23me3 is a RNAi-mediated transgenerationally heritable heterochromatin mark in Caenorhabditis elegans.
    1. Neuroscience

    Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1

    Nengyin Sheng et al.
    Auxiliary subunits Neto1 and Neto2 regulate the GluK1 receptor targeting to excitatory silent synapses through different molecular mechanisms and also modify receptor biophysics through distinct mechanisms.
    1. Microbiology and Infectious Disease

    Multimeric single-domain antibody complexes protect against bunyavirus infections

    Paul J Wichgers Schreur et al.
    Llama-derived single-domain antibodies, formatted as bispecific antibodies with human Fc domains, reduce and prevent bunyavirus-induced morbidity and mortality in mice upon prophylactic and therapeutic administration.
    1. Chromosomes and Gene Expression

    Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness

    Zuodong Zhao et al.
    Sustained TNF-α induction consolidates transcriptional memory for faster, stronger, and more sensitive subsequent induction in an active DNA demethylation-dependent manner for memory genes including CALCB, a therapeutic target for migraine.
    1. Cell Biology
    2. Neuroscience

    Filamin, a synaptic organizer in Drosophila, determines glutamate receptor composition and membrane growth

    GaYoung Lee, Thomas L Schwarz
    Filamin, by recruiting a signaling complex to the postsynapse, orchestrates the correct formation and growth of postsynaptic membranes and localization of glutamate receptor subunits.
    1. Evolutionary Biology
    2. Neuroscience

    Physiological constraint on acrobatic courtship behavior underlies rapid sympatric speciation in bearded manakins

    Meredith C Miles et al.
    Skeletal muscle performance sets the course of rapid speciation by defining the evolutionary trajectory of reproductive behavior.

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