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    1. Neuroscience

    Decoding subjective emotional arousal from EEG during an immersive virtual reality experience

    Simon M Hofmann, Felix Klotzsche ... Michael Gaebler
    Modulations of alpha oscillations from parieto-occipital brain regions can be used to decode subjective emotional arousal in a dynamic naturalistic virtual reality experience.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Species-wide whole genome sequencing reveals historical global spread and recent local persistence in Shigella flexneri

    Thomas R Connor, Clare R Barker ... Nicholas R Thomson
    Shigella flexneri, globally the most frequent cause of bacterial dysentery, is far more diverse, and has caused disease around the world for far longer than other Shigella species by persisting in local environments over extended timescales.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers

    Vladislav Belyy, Iratxe Zuazo-Gaztelu ... Peter Walter
    Stress sensors in the membrane of the endoplasmic reticulum respond to the accumulation of unfolded proteins by briefly forming small phosphorylation-competent oligomers and dissolving back into active dimers.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Signatures of transposon-mediated genome inflation, host specialization, and photoentrainment in Entomophthora muscae and allied entomophthoralean fungi

    Jason E Stajich, Brian Lovett ... Carolyn Elya
    Entomophthora muscae has one of the largest fungal genomes (1.03 Gb) owing to extensive proliferation of transposable elements.
    1. Chromosomes and Gene Expression

    Transcription dynamically patterns the meiotic chromosome-axis interface

    Xiaoji Sun, Lingzhi Huang ... Andreas Hochwagen
    Distributed cohesin rings flexibly tether the axial element structure of meiotic chromosomes to the underlying chromatin to readily accommodate ongoing transcription.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A functional link between the co-translational protein translocation pathway and the UPR

    Rachel Plumb, Zai-Rong Zhang ... Malaiyalam Mariappan
    Ire1α co-opts the Sec61 translocon channel to efficiently cleave its mRNA substrates during endoplasmic reticulum stress conditions.
    1. Neuroscience

    Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat

    Hala Harony-Nicolas, Maya Kay ... Joseph D Buxbaum
    The production, validation and study of a novel rat model for Phelan McDermid Syndrome shows an ameliorative effect of oxytocin on both social and attentional deficits.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome

    Yoong Wearn Lim, Lionel A Sanz ... Frédéric Chédin
    Global epigenetic perturbations and accumulation of RNA:DNA hybrids are two novel hallmarks of the lupus-like inflammatory disorder Aicardi-Goutières syndrome.
    1. Computational and Systems Biology
    2. Neuroscience

    Interpersonal alignment of neural evidence accumulation to social exchange of confidence

    Jamal Esmaily, Sajjad Zabbah ... Bahador Bahrami
    A multidisciplinary approach sheds light on the fundamental mechanisms underlying social belief communication under uncertainty.
    1. Neuroscience

    Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss

    Fredrick E Henry, Ken Sugino ... Scott M Sternson
    Cell type-specific transcriptomics in energy homeostasis neurons has identified hundreds of genes and multiple signaling pathways that are regulated by weight loss in mice, as well as several previously unexamined genes that can regulate appetite and body weight.