5,540 results found
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma

    Ana R Grosso et al.
    Transcription beyond annotated gene boundaries expands the diversity of the cancer transcriptome with overexpressed oncogenes and RNA chimeras.
    1. Chromosomes and Gene Expression

    PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading

    Gergely Rona et al.
    Upon genotoxic stress, the FBXL10-RNF68-RNF2 ubiquitin ligase complex mono-ubiquitylates histone H2A and mediates H2A/H2A.Z exchange to repress transcription and ensures proper high fidelity homologous recombination repair.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema

    Ran You et al.
    The accumulation of carbon black nanoparticles in smokers' lungs causes sterile inflammation, double-strand DNA breaks and emphysema.
    1. Cell Biology
    2. Developmental Biology

    Germ Granules: All about the RNA after all

    Tatjana Trcek, Ruth Lehmann
    RNA molecules cause the proteins involved in the formation of germ granules to coalesce into liquid droplets.
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    1. Cell Biology
    2. Chromosomes and Gene Expression

    Chromocenters: Bundling up DNA

    Susan A Gerbi
    Structures known as chromocenters, comprising satellite DNA and proteins such as D1 or HMGA1, help to contain DNA inside the nucleus between cell divisions.
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    1. Cell Biology
    2. Chromosomes and Gene Expression

    Heterochromatin: Silencing repetitive DNA

    Nahid Iglesias, Danesh Moazed
    Some RNAs in mammalian cells can help to silence the DNA they are transcribed from.
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    1. Biochemistry and Chemical Biology

    In Vitro Evolution: Rethinking the tools of the RNA world

    Antony Crisp, Thomas Carell
    An artificially evolved ribozyme can catalyse the synthesis of RNA by using trinucleotide triphosphates as building blocks.
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    1. Biochemistry and Chemical Biology

    Intracellular Organization: Getting ready for DNA duplication

    Nina Y Yao, Michael E O'Donnell
    The discovery of a biomolecular condensate involved in DNA replication has wide ranging implications.
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    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Protein-mediated RNA folding governs sequence-specific interactions between rotavirus genome segments

    Alexander Borodavka et al.
    In rotaviruses, the selective packaging of eleven distinct genomic RNA segments requires virus-encoded protein NSP2 to alter the RNA structures, facilitating their interactions with each other.
    1. Chromosomes and Gene Expression

    Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication

    Carl A Morrow et al.
    The discovery of a mechanism that causes DNA deletions during non-canonical DNA replication termination is described.

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