Integrating chromatin accessibility and gene expression data into context-specific regulatory networks can provide better regulatory categories for heritability enrichment and relevant tissue identification.

High-fat ingestion triggers microglial metabolic activation within a single feeding cycle, and enhances whole-body metabolism and memory by converting fatty acids into protective substrates for surrounding neurons.

Regulatory T cells produce analgesic opioid peptides that limit heat sensitivity in mice, revealing a novel pain regulation mechanism independent of inflammation control.

Female mosquitoes are exquisitely sensitive to human body heat, and the TRPA1 gene is required to focus their attraction toward thermal stimuli resembling warm-blooded hosts.

A history of coevolution increases genetic variation in the susceptibility of Drosophila to viruses, largely by introducing major-effect resistance polymorphisms into populations.

Serum response factor (SRF) deficient reactive astrocytes are neuroprotective in the mammalian brain.

Single-cell transcriptome analysis of sacral compared with vagal neural crest-derived cells in the developing chick enteric nervous system reveals both similarities and differences between these two cell populations.

Notch signaling alters TLR-induced inflammation by skewing monocyte cell fate toward patrolling monocyte differentiation at the expense of macrophage cell fate.

Computational modeling motivated by recent experiments clarifies biophysical mechanisms generating the rhythm and amplitude of breathing at the level of neurons and brain circuits in mammals.

The transcriptional response of human neurons to calcium ion signals shows evolutionary divergence from those responses elicited in mouse neurons, providing evidence in favour of using human systems to study neuronal responses to external stimuli.