1,859 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway

    Zhiyun Ge et al.
    The RNA-binding protein PTBP1 is recruited to sites near stop codons in retroviral and human mRNAs, shielding them from detection and degradation by the nonsense-mediated mRNA decay pathway.
    1. Cell Biology

    Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability

    Jonathan O Nelson et al.
    Excess expression of the Gadd45 mRNA accounts for lethality when nonsense-mediated decay is lost in Drosophila and mammalian cells, revealing that this pathway is a critical gene regulatory mechanism.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Quality control of transcription start site selection by nonsense-mediated-mRNA decay

    Christophe Malabat et al.
    RNA polymerase II generates numerous transcript isoforms, including transcripts initiating downstream of the START codon, that are efficiently degraded by the nonsense-mediated mRNA decay pathway.
    1. Biochemistry and Chemical Biology

    Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase

    Elizabeth V Wasmuth et al.
    The nuclear exosome cofactors Mpp6 and Rrp47 can stimulate exoribonuclease activities of the nuclear RNA exosome and recruit the Mtr4 helicase to promote helicase dependent RNA decay.
    1. Chromosomes and Gene Expression

    Multiple decay events target HAC1 mRNA during splicing to regulate the unfolded protein response

    Patrick D Cherry et al.
    RNA decay is used at multiple points in the budding yeast unfolded protein response to regulate its suppression and activation, and possibly its attenuation.
    1. Cell Biology

    Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe

    Nicholas R Guydosh et al.
    A critical component of the cellular response to unfolded proteins is the widespread rescue of ribosomes that stall on endonucleolytically-cleaved mRNA transcripts.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay

    Jirka Peschek, Peter Walter
    Interconnected RNA processing mechanisms ensure the fidelity of non-conventional mRNA splicing during the unfolded protein response.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    ICE1 promotes the link between splicing and nonsense-mediated mRNA decay

    Thomas D Baird et al.
    A whole-genome siRNA screen identifies ICE1 as a factor required for accurate sensing and quality control of mRNAs containing premature stop codons.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability

    Leon Y Chan et al.
    Non-invasive mRNA stability measurements reveal that transcript lifetime is governed by a competition with translation initiation on a transcriptome-wide level.
    1. Chromosomes and Gene Expression

    Nonsense mRNA suppression via nonstop decay

    Joshua A Arribere, Andrew Z Fire
    Nonstop mRNA decay degrades mRNAs with a premature stop codon after such mRNAs are targeted by the nonsense-mediated decay machinery.

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