2,854 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway

    Zhiyun Ge et al.
    The RNA-binding protein PTBP1 is recruited to sites near stop codons in retroviral and human mRNAs, shielding them from detection and degradation by the nonsense-mediated mRNA decay pathway.
    1. Cell Biology

    Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability

    Jonathan O Nelson et al.
    Excess expression of the Gadd45 mRNA accounts for lethality when nonsense-mediated decay is lost in Drosophila and mammalian cells, revealing that this pathway is a critical gene regulatory mechanism.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Quality control of transcription start site selection by nonsense-mediated-mRNA decay

    Christophe Malabat et al.
    RNA polymerase II generates numerous transcript isoforms, including transcripts initiating downstream of the START codon, that are efficiently degraded by the nonsense-mediated mRNA decay pathway.
    1. Chromosomes and Gene Expression

    A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay

    William R Brothers et al.
    Crosslink immunopreciptiation (iCLIP) studies reveal important mechanistic insights into how MARF1 post-transcriptionally regulates targeted mRNAs and uncover a novel mode by which EDC4 regulates mRNA metabolism.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis

    Christopher Duncan-Lewis et al.
    Human cells respond to cytoplasmic mRNA depletion during early apoptosis by inhibiting RNA polymerase II transcription, thereby magnifying the gene expression shutdown during stress.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    ICE1 promotes the link between splicing and nonsense-mediated mRNA decay

    Thomas D Baird et al.
    A whole-genome siRNA screen identifies ICE1 as a factor required for accurate sensing and quality control of mRNAs containing premature stop codons.
    1. Chromosomes and Gene Expression

    Nonsense mRNA suppression via nonstop decay

    Joshua A Arribere, Andrew Z Fire
    Nonstop mRNA decay degrades mRNAs with a premature stop codon after such mRNAs are targeted by the nonsense-mediated decay machinery.
    1. Structural Biology and Molecular Biophysics

    Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM

    Andres López-Perrote et al.
    Cryo-EM reveals the regulation of RUVBL1 and RUVBL2 AAA-ATPases by DHX34, a helicase involved in nonsense-mediated mRNA decay (NMD), and suggests mechanisms for how RUVBL1 and RUVBL2 function in NMD.
    1. Chromosomes and Gene Expression

    Multiple decay events target HAC1 mRNA during splicing to regulate the unfolded protein response

    Patrick D Cherry et al.
    RNA decay is used at multiple points in the budding yeast unfolded protein response to regulate its suppression and activation, and possibly its attenuation.
    1. Cell Biology

    Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe

    Nicholas R Guydosh et al.
    A critical component of the cellular response to unfolded proteins is the widespread rescue of ribosomes that stall on endonucleolytically-cleaved mRNA transcripts.

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