1,163 results found
    1. Structural Biology and Molecular Biophysics

    A novel pH-dependent membrane peptide that binds to EphA2 and inhibits cell migration

    Daiane S Alves et al.
    The transmembrane domain of the EphA2 receptor has been transformed into a novel amphitropic peptide that binds to the EphA2 receptor and inhibits cell migration.
    1. Plant Biology

    A plant chitinase controls cortical infection thread progression and nitrogen-fixing symbiosis

    Anna Malolepszy et al.
    Lotus japonicus chitinase modulates the level of rhizobial Nod factor and thereby enables cortical infection and functional symbiosis in root nodules.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria

    Alam García-Heredia et al.
    Peptidoglycan precursor synthesis occurs in both growing and non-growing regions of the mycobacterial cell surface.
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon et al.
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    New insights into the cellular temporal response to proteostatic stress

    Justin Rendleman et al.
    A time-resolved analysis of protein and RNA concentrations and interactions during proteostasis stress highlights the dominant role of translation regulation and a shift of energy metabolism.
    1. Neuroscience

    ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines

    Shu-Xia Cao et al.
    Behavioral and molecular mechanistic studies elaborate the important role of ErbB4 in noradrenergic neurons associated with mania pathogenesis.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    UBE2G1 governs the destruction of cereblon neomorphic substrates

    Gang Lu et al.
    Cereblon-based small-molecule degraders rely on the sequential action of ubiquitin-conjugating enzymes UBE2G1 and UBE2D3 to assemble K48-linked polyubiquitin chains on cereblon neomorphic substrates, resulting in their proteasomal degradation.
    1. Cell Biology
    2. Neuroscience

    High N-glycan multiplicity is critical for neuronal adhesion and sensitizes the developing cerebellum to N-glycosylation defect

    Daniel Medina-Cano et al.
    Impairment of protein N-glycosylation disrupts neural cell adhesion mediated by highly glycosylated members of the IgSF-CAM protein family.
    1. Cell Biology

    Mitochondria reorganization upon proliferation arrest predicts individual yeast cell fate

    Damien Laporte et al.
    Mitochondria morphology can be use to identify quiescent and senescent yeast cells.
    1. Developmental Biology

    Par3 interacts with Prickle3 to generate apical PCP complexes in the vertebrate neural plate

    Ilya Chuykin et al.
    Par3 is polarized in the plane of the vertebrate neural plate, binds and recruits Prickle3 to the apical membrane and promotes the formation of core planar cell polarity complexes.

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