1,163 results found
    1. Evolutionary Biology
    Paleontology

    Paleontology: A Collection of Articles

    Curated by Ian Baldwin et al.
    eLife has published papers on topics as diverse as paleoproteomics, ancient insects and the discovery of a new hominin species.
  1. September 2016

    Episode 32: September 2016

    In this episode we hear about ancient proteins, aging mice, mosquito nets, resourceful plants and cocktail party conversations.
  2. July 2013

    Episode 2: July 2013

    In this episode we hear about plants doing maths, the evolution of cancer, why blood vessels don'€™t grow in the retina, the immune system and more.
  3. January 2015

    Episode 17: January 2015

    In this episode we hear about controlling sperm by optogenetics, hibernation, body clocks, enzyme structure, and a way to overcome stress-induced infertility.
    1. Cell Biology
    2. Immunology and Inflammation

    A two-hybrid antibody micropattern assay reveals specific in cis interactions of MHC I heavy chains at the cell surface

    Cindy Dirscherl et al.
    A generally applicable two-hybrid assay demonstrates that MHC class I heavy chains devoid of beta-2 microglobulin associate within and across allotypes, with implications for endocytosis and autoimmunity.
    1. Neuroscience

    Neuropathological and transcriptomic characteristics of the aged brain

    Jeremy A Miller et al.
    High variability in neuropathology burden and interactions between dementia diagnosis and RNA quality present underappreciated complications when studying dementia in an aged population.
    1. Computational and Systems Biology
    2. Developmental Biology

    A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

    Qixuan Wang et al.
    Regional differences in activator and inhibitor signals alter hair cycle pace across mouse skin and produce unique fur renewal 'landscapes', with fastest renewal on the ventrum and slowest renewal on the ear pinnae.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure

    Jieqiong Gao et al.
    The endosomal GEF Mon1-Ccz1 binds to Atg8 on autophagosomes, and recruits its substrate, the Rab7-like Ypt7, which then mediates fusion of the autophagosomes with the lysosome.
    1. Structural Biology and Molecular Biophysics

    Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions

    Ben Sorum et al.
    In the CFTR chloride channel, ATP bound in the catalytic site promotes pore opening, whereas ATP bound in the non-catalytic site supports unidirectional conformational cycling by preventing pore closure without ATP hydrolysis in the catalytic site.
    1. Neuroscience

    A zebrafish and mouse model for selective pruritus via direct activation of TRPA1

    Kali Esancy et al.
    A pain-relaying ion channel on a hypersensitive population of sensory neurons can instead elicit sensations of itch in both fish and mice when directly activated, providing a novel model of itch transduction.

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