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    1. Developmental Biology and Stem Cells

    Signaling: Enzymatic insights into an inherited genetic disorder

    Liping Zhang, Kelly G Ten Hagen
    Mutations in an enzyme involved in protein degradation affect a signaling pathway that stimulates the development of the digestive tract.
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    1. Cell Biology

    mRNA Decay: How cells kill a "killer" messenger

    Cosmin Saveanu, Alain Jacquier
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    1. Cancer Biology
    2. Cell Biology

    Mathematical Modeling: Tuning the MYC response

    Ying Zheng, David Levens
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    1. Cell Biology

    Cell Biology: New twists in the unfolded protein response

    Benedict C S Cross, David Ron
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    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Biophysics and Structural Biology
    2. Microbiology and Infectious Disease

    Biofilms: Flipping the switch

    Xavier Pierrat, Alexandre Persat
    A structural switch controls the architecture of Vibrio cholerae biofilms by mediating the interactions between two matrix components.
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    1. Cell Biology
    2. Human Biology and Medicine

    Prostate Cancer: SPOP the mutation

    Leah Rider, Scott D Cramer
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    1. Cancer Biology

    Science Forum: Challenges in validating candidate therapeutic targets in cancer

    Jeffrey Settleman et al.
    More than 30 published articles have suggested that a protein kinase called MELK is an attractive therapeutic target in human cancer, but three recent reports describe compelling evidence that it is not.